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Vol. 28 No. 7 (2016): Vol 28 Issue 7

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Synthesis, Spectral Characterization, Grain Size Effect, Antimicrobial, DNA Cleavage and Anticancer Activities of Cobalt(II), Nickel(II), Copper(II) and Zinc(II) Complexes of Schiff Base

https://doi.org/10.14233/ajchem.2016.19757
R. Selwin Joseyphus
Department of Chemistry, Mar Ivanios College (Autonomous), Thiruvananthapuram-695 015, India
Israr-ul-Hassan
Department of Mathematics and Sciences, College of Arts and Applied Sciences, Dhofar University, P.O. Box 2509, PC 211, Salalah, Oman
Gowhar Ahmad Naikoo
Department of Mathematics and Sciences, College of Arts and Applied Sciences, Dhofar University, P.O. Box 2509, PC 211, Salalah, Oman

Corresponding Author(s) : R. Selwin Joseyphus

rsjoseyphus@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 7 (2016): Vol 28 Issue 7

Abstract

A series of cobalt(II), nickel(II), copper(II) and zinc(II) complexes were synthesized with a newly prepared Schiff base ligand. The ligand was prepared by the condensation of indole-3-carboxaldehyde with 2-amino-3-carboxyethyl-4,5-dimethylthiophene (1:1 molar ratio). The complexes were characterized by elemental analysis, molar conductance, magnetic moment, UV-visible, IR, 1H NMR and mass spectrometric techniques. From the results of physico-chemical and spectral techniques, tetrahedral and square planar geometry have been proposed for these metal complexes. The crystallinity and surface morphologies of the metal-complexes were examined by powder XRD and SEM. Antibacterial and antifungal activities of the metal-complexes were screened by Kirby-Bauer disk diffusion method. DNA cleavage was investigated using the Gel-electrophoresis method. The super oxide anion scavenging and anticancer activities of the metal-complexes against HeLa cell line were determined using MTT assay.

Keywords

Indole-3-carboxaldehyde Schiff base XRD SEM DNA Anticancer
Joseyphus, R. S., Israr-ul-Hassan, ., & Naikoo, G. A. (2016). Synthesis, Spectral Characterization, Grain Size Effect, Antimicrobial, DNA Cleavage and Anticancer Activities of Cobalt(II), Nickel(II), Copper(II) and Zinc(II) Complexes of Schiff Base. Asian Journal of Chemistry, 28(7), 1571–1574. https://doi.org/10.14233/ajchem.2016.19757
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