Efficient and Mild Synthesis of 2-Aryl-Substituted 2,3-Dihydroquinazolin-4(1H)-Ones Catalyzed by NaHSO4

Abstract

Sodium hydrogen sulfate efficiently catalyzed in the condensation of anthranilamide with aromatic aldehydes under room temperature to afford 2-aryl-2,3-dihydroquinazolin-4(1H)-ones in good yields and high purity. This methodology offers significant improvements with regard to the yield of products, inexpensive reagents and green aspects by avoiding toxic catalysts.