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Vol. 28 No. 7 (2016): Vol 28 Issue 7

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Preparation of Curcumin-Loaded Egg Albumin Nanoparticles Using Ethanol as Desolvation Agent

https://doi.org/10.14233/ajchem.2016.19754
D.S. Aniesrani Delfiya
Department of Food and Agricultural Process Engineering, Tamil Nadu Agricultural University, Coimbatore-641 003, India
K. Thangavel
Department of Fruit Crops, Horticultural College and Research Institute, Tamil Nadu Agricultural University, Periyakulam-625 604, India
N. Natarajan
Department of Nano Science and Technology, Tamil Nadu Agricultural University, Coimbatore-641 003, India
D. Amirtham
Department of Food and Agricultural Process Engineering, Tamil Nadu Agricultural University, Coimbatore-641 003, India

Corresponding Author(s) : D.S. Aniesrani Delfiya

delfy.lenin@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 7 (2016): Vol 28 Issue 7

Abstract

Curcumin-loaded egg albumin nanoparticles were prepared by desolvation method using ethanol as desolvation agent. In this study, effect of factors viz. egg albumin concentration (5-15 % w/v) and pH (5-7) of egg albumin solution on solubility, curcumin loading, curcumin entrapment efficiency, nanoparticles yield and particle size of the prepared nanoparticles were investigated. Preparation process was optimized by the response surface methodology-central composite design of experiments. Under the optimum conditions of 8.06 % (w/v) egg albumin concentration and pH of 5.34, maximum solubility of 30.54 %, curcumin loading of 5.78 %, curcumin entrapment efficiency of 56.78 %, yield of 71.65 % and minimum particles size of 263.5 nm are achievable. Response surface methodology was found to be an effective tool to describe the effect of independent variables on quality characteristics of prepared curcumin-egg albumin nanoparticles and optimize the process parameters.

Keywords

Curcumin Egg albumin nanoparticles Desolvation Ethanol
Aniesrani Delfiya, D., Thangavel, K., Natarajan, N., & Amirtham, D. (2016). Preparation of Curcumin-Loaded Egg Albumin Nanoparticles Using Ethanol as Desolvation Agent. Asian Journal of Chemistry, 28(7), 1536–1544. https://doi.org/10.14233/ajchem.2016.19754
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