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Vol. 24 No. 3 (2012): Vol 24 Issue 3

Rapid Determination of Four Tobacco-Specific Nitrosamines in Mainstream Cigarette Smoke by UPLC-TOF-MS

Sai-Jing Zheng
Key Laboratory of Cigarette Smoke Research of China National Tobacco Corporation, Shanghai 200082, P.R. China
Jun Yang
Key Laboratory of Cigarette Smoke Research of China National Tobacco Corporation, Shanghai 200082, P.R. China; Department of Chemistry, University of Science and Technology of China, Hefei 230026, P.R. China
Bai-Zhan Liu
Key Laboratory of Cigarette Smoke Research of China National Tobacco Corporation, Shanghai 200082, P.R. China
Wen-Jing Zhu
Department of Chemistry, University of Science and Technology of China, Hefei 230026, P.R. China
Li Yao
Department of Chemistry, University of Science and Technology of China, Hefei 230026, P.R. China
Wen-Bo Gu
Key Laboratory of Cigarette Smoke Research of China National Tobacco Corporation, Shanghai 200082, P.R. China
Rong Qian
Key Laboratory of Cigarette Smoke Research of China National Tobacco Corporation, Shanghai 200082, P.R. China

Corresponding Author(s) : Jun Yang

yjun8202@ustc.edu.cn

Asian Journal of Chemistry, Vol. 24 No. 3 (2012): Vol 24 Issue 3

Abstract

A rapid method for determining four major tobacco-specific nitrosamines (TSNAs) in mainstream cigarette smoke based on ultra-performance liquid chromatography coupled to time-offlight mass spectrometry (UPLC-TOF-MS) has been developed. Cigarette smoke particulate, collected on a Cambridge filter pad, was extracted by using ammonium acetate buffer as solvent, purified by solid phase extraction (SPE) and analyzed by UPLC-TOF-MS with positive electrospray ionization (ESI+). The method has shown excellent sensitivity, repeatability and accuracy.

Keywords

UPLC-TOF-MS Tobacco-specific nitrosamines Mainstream cigarette smoke Solid phase extraction
Zheng, S.-J., Yang, J., Liu, B.-Z., Zhu, W.-J., Yao, L., Gu, W.-B., & Qian, R. (2011). Rapid Determination of Four Tobacco-Specific Nitrosamines in Mainstream Cigarette Smoke by UPLC-TOF-MS. Asian Journal of Chemistry, 24(3), 1147–1150. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/8728
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