Synthesis and Biological Evaluation of Some New 2,4,6-Trisubstituted Pyrimidines

S. Sridhar; Y. Rajendra Prasad; S.C. Dinda

Issue

Vol. 24 No. 3 (2012): Vol 24 Issue 3

Issue Published : November 2, 2011

Synthesis and Biological Evaluation of Some New 2,4,6-Trisubstituted Pyrimidines

S. Sridhar

Malla Reddy College of Pharmacy, Secunderabad-500 014, India

Y. Rajendra Prasad

University College of Pharmaceutical Sciences, Andhra University, Vishakapatanam-530 003, India

S.C. Dinda

School of Pharmaceutical Education and Research, Berhampur University, Berhampur-760 007, India

Corresponding Author(s) : S. Sridhar

sridhar_pharma24@yahoo.co.in

Asian Journal of Chemistry, Vol. 24 No. 3 (2012): Vol 24 Issue 3
Article Published : December 13, 2011

Abstract

In the present study, 3-acetyl-2,5-dimethylfuran on condensation with various aromatic and heterocyclic aldehydes in ethanolic KOH solution yielded the corresponding chalcones (3a-n). These chalcones were reacted with guanidine hydrochloride in presence of potassium hydroxide and ethanol to give pyrimidines (4a-n). All these compounds were characterized by IR, ¹H NMR spectroscopic data and microanalyses. When these compounds were evaluated for antiinflammatory and antimicrobial activities, some of them were found to possess significant activity, when compared to standard drugs.

Keywords

Pyrimidines Synthesis Antimicrobial activity

Sridhar, S., Rajendra Prasad, Y., & Dinda, S. (2011). Synthesis and Biological Evaluation of Some New 2,4,6-Trisubstituted Pyrimidines. Asian Journal of Chemistry, 24(3), 1130–1134. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/8725

Issue

Vol. 24 No. 3 (2012): Vol 24 Issue 3

Synthesis and Biological Evaluation of Some New 2,4,6-Trisubstituted Pyrimidines

Corresponding Author(s) : S. Sridhar

Abstract

Keywords

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