Synthesis of Ethyl and Phenyl Amido(Ethoxyphenylalaninyl)Phosphate Compounds

Abstract

The synthetic route for preparation of three phosphoramides containing amino acid and their precursors in good yield and mild conditions is reported. This involved the synthesis of the ethyl and phenyl phosphorodichloridate and its reaction with bis(b-chloroethyl) amine or diethylamine, followed by the reaction of the products with phenyl alanine ethyl ester hydrochloride. In all the three compounds, because of the presence of chiral centre, the final products were obtained as a mixture of two diastereoisomers, which can be determined using ³¹P NMR and TLC methods. The structures of all the prepared compounds were confirmed by ¹H NMR, ³¹P NMR, ¹³C NMR spectroscopy.