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Optimization of Coating Process by Using Design of Experiment and Thermodynamic Environment Equivalency Factor
Corresponding Author(s) : Pratap Kumar Sahu
Asian Journal of Chemistry,
Vol. 28 No. 7 (2016): Vol 28 Issue 7
Abstract
This study identifies and screens the critical process parameters by design of experiments and then optimizes it further using the environmental equivalency factor. Film-coating of tablets is a process in which distinct variables and the factors (core composition, process conditions and coating suspension). The process parameters identified during the process include inlet air temperature, air pressure, spray rate and the responses reflected on surface roughness and loss on drying. An initial screening was done using the 23 full factorial design, where the surface roughness is found to be in the range of 2.25 to 2.97. Loss on drying is measured was found to be varying between 1.35 to 2.62. The environmental equivalency factor is expressed by an equation involving ten individual parameters using the software ‘TAAC and found to be in the range of 2.486 to 8.063. The final optimization was carried out by using two different techniques viz. “design of experiment” and “environmental equivalency” factor.
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- M. Ruotsalainen, Academic Dissertation, Department of Pharmacy, University of Helsinki, Helsinki, Finland (2003).
- S. Page, K.H. Baumann and P. Kleinebudde, AAPS PharmSciTech, 7, E1 (2006); doi:10.1208/pt070231.
- K. Walter, Pharm. Eng., 27, 1 (2007).
- M.T. Ende and A. Berchielli, Pharm. Dev. Technol., 10, 47 (2005); doi:10.1081/PDT-200035915.
- S.C. Porter, R.P. Verseput and C.R. Cunningham, Pharm. Technol., 2, 160 (1997).
- K.P.R. Chowdary and Ch. Tarakaramarao, Asian J. Chem., 23, 958 (2011).
- J.C. Strong, AAPS PharmSciTech, 10, 303 (2009); doi:10.1208/s12249-009-9204-7.
- N. Sheth, S. Shah, A. Potdar and A. Shah, Int. J. Pharm. Sci. Nanotechnol., 2, 621 (2009).
- R. Mohapatra and S. Mallick, Asian J. Chem., 28, 1149 (2016); doi:10.14233/ajchem.2016.19614.
- J.K. Patel, A.M. Shah and N.R. Sheth, Int. J. Pharm. Tech. Res., 1, 235 (2009).
- Moisture Determination with Halogen Moisture Analyzer, Mettler-Toledo AG Laboratory & Weighing Technologies, CH-8606, Greifensee, Switzerland.
- http://in.mt.com/dam/product_organizations/laboratory_weighing/moisture/products/hb43_s/documentation/en/HB43-S_OI_en_11780961A.pdf.
- Thermodynamic Analysis of Aqueous Film Coating, Program User’s Guide- Thomas Engineering Inc.
References
M. Ruotsalainen, Academic Dissertation, Department of Pharmacy, University of Helsinki, Helsinki, Finland (2003).
S. Page, K.H. Baumann and P. Kleinebudde, AAPS PharmSciTech, 7, E1 (2006); doi:10.1208/pt070231.
K. Walter, Pharm. Eng., 27, 1 (2007).
M.T. Ende and A. Berchielli, Pharm. Dev. Technol., 10, 47 (2005); doi:10.1081/PDT-200035915.
S.C. Porter, R.P. Verseput and C.R. Cunningham, Pharm. Technol., 2, 160 (1997).
K.P.R. Chowdary and Ch. Tarakaramarao, Asian J. Chem., 23, 958 (2011).
J.C. Strong, AAPS PharmSciTech, 10, 303 (2009); doi:10.1208/s12249-009-9204-7.
N. Sheth, S. Shah, A. Potdar and A. Shah, Int. J. Pharm. Sci. Nanotechnol., 2, 621 (2009).
R. Mohapatra and S. Mallick, Asian J. Chem., 28, 1149 (2016); doi:10.14233/ajchem.2016.19614.
J.K. Patel, A.M. Shah and N.R. Sheth, Int. J. Pharm. Tech. Res., 1, 235 (2009).
Moisture Determination with Halogen Moisture Analyzer, Mettler-Toledo AG Laboratory & Weighing Technologies, CH-8606, Greifensee, Switzerland.
Thermodynamic Analysis of Aqueous Film Coating, Program User’s Guide- Thomas Engineering Inc.