Synthesis of Montelukast-Androsterone Derivative and its Relationship with Physico-chemical Descriptors log P, p, Rm, Vm, Pc and St

Abstract

In this work our initial design included the synthesis of montelukast-androsterone (5) and its relationship with several physico-chemical parameters as log P, p, R_m, V_m, P_C and S_T. The first step was achieved by the reacting between hemisuccinate of androsterone (1) with ethyleneadiamine to form an androsterone derivative (3) using N-(3-dimethylaminopropyl)-N'- ethylcarbodiimide or boric acid as catalysts. In the second stage, was achieved by reacting 3 with montelukast (4) to form 5 in presence of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide. Other results showed an increase in the values of log P, p, R_m, V_m, P_C and S_T in 5 with respect to 1, 3 and 4. These data suggest that physico-chemical parameters can affect the degree of lipophilicity of 5.