Isolation and Evaluation of Antinociceptive Activity of Sulfur-Containing Iridoid Glucosides from Paederia scandens
Di Jin
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, P.R. China; Harbin University of Commerce, Harbin 150076, P.R. China
Zhixiong Li
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, P.R. China
Mingcang Chen
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, P.R. China
Mingsong Fan
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, P.R. China
Zhaolin Sun
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, P.R. China
Weixin Jiang
Harbin University of Commerce, Harbin 150076, P.R. China
Bin Wu
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, P.R. China
Chenggang Huang
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, P.R. China
Corresponding Author(s) : Bin Wu
cghsimm@126.com
Asian Journal of Chemistry,
Vol. 24 No. 2 (2012): Vol 24 Issue 2
Isolate and purify the sulfur-containing iridoid glucosides from Paederia scandens. Three sulfurcontaining iridoid glucosides (1-3) were isolated and the structures of them were elucidated as paederosides (1), paederosidic acid (2) and paederosidic acid methyl ester (3) by spectroscopic analysis. The sulfur-containing iridoid glucosides were evaluated on antinociceptive activity in mice using thermal models of nociception. Both paederosidic acid (2, 120 mg/kg, i.g. or 70 mg/ kg, i.p.) and paederosidic acid methyl ester (3, 70 mg/kg, i.p.) produced significant inhibitory activity on thermal nociception in the hot plate test. Paederoside (1, 70 mg/kg, i.p.) had not produced significant antinociceptive effects in the hot plate test.
Jin, D., Li, Z., Chen, M., Fan, M., Sun, Z., Jiang, W., … Huang, C. (2011). Isolation and Evaluation of Antinociceptive Activity of Sulfur-Containing Iridoid Glucosides from Paederia scandens. Asian Journal of Chemistry, 24(2), 538–540. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/8595