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Vol. 25 No. 17 (2013): Vol 25 Issue 17

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A Bioactive Alkaloid from the Fruit of Coccinia grandis

https://doi.org/10.14233/ajchem.2013.15078
Swarnali Nath Choudhury
Department of Science and Technology, ICFAI University Tripura, Kamalghat, Agartala-799 210, India
S.B. Paul
Department of Chemistry, Assam University, Dargakona, Silchar-788 011, India
Biplab De
Regional Institute of Pharmaceutical Science and Technology, Abhoynagar, Agartala-799 005, India

Corresponding Author(s) : Biplab De

biplab_32@yahoo.co.in

Asian Journal of Chemistry, Vol. 25 No. 17 (2013): Vol 25 Issue 17

Abstract

The analgesic activity of the methanolic extract of leaf of Coccinia grandis and its separated fractions were studied in acetic acid induced model. The in vivo antiinflammatory was also studied using Carageenan induced rat paw edema method. The result of both the studies indicated that the extract and its components possessed significant analgesic activity as well anti-inflammatory activity at the dose 100 mg/Kg bw. Both the activities were compared with standard drug aspirin for analgesic and diclofenac sodium for antiinflammatory. The structure of the bioactive compound has been characterized on the basis of spectral data such as IR, 1H NMR, 13C NMR and mass spectral studies.

Keywords

Coccina grandis Analgesic activity Antiinflammatory activity
Nath Choudhury, S., Paul, S., & De, B. (2013). A Bioactive Alkaloid from the Fruit of Coccinia grandis. Asian Journal of Chemistry, 25(17), 9561–9564. https://doi.org/10.14233/ajchem.2013.15078
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