Triterpenoides from the Leaves of Ilex pubescens and their Potential Xanthine Oxidase Inhibitory Activity
Corresponding Author(s) : Zhong-Liu Zhou
Asian Journal of Chemistry,
Vol. 25 No. 17 (2013): Vol 25 Issue 17 page 9457-9459
A new triterpene saponin, ilexsaponin B (1), along with three known triterpenoides, 2a, 3b, 19a, 23-tetrahydroxy oleanolic acid (2), ilexgenin A (3) and ilexolide A (4) were isolated from the leaves of Ilex pubescens. Their chemical structures were elucidated on the basis of UV, IR, MS, NMR spectroscopic analyses coupled with chemical degradation. In addition, the xanthine oxidase inhibitory activity of the isolated compounds was reported. Compound 1 exhibited moderate xanthine oxidase inhibitory activity in the test with an IC50 value of 26.01 μmol/L.
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