Synthesis and in vitro Antifungal Activity of Phosphate Esters

Mithilesh Kumari Gupta; S.K. Jadhav; S.A. Bhoite

doi:10.14233/ajchem.2016.19744

Issue

Vol. 28 No. 7 (2016): Vol 28 Issue 7

Issue Published : March 31, 2016

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and in vitro Antifungal Activity of Phosphate Esters

https://doi.org/10.14233/ajchem.2016.19744

Mithilesh Kumari Gupta

School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 India

S.K. Jadhav

School of Studies in Biotechnology, Pt. Ravishankar Shukla University, Raipur-492 010 India

S.A. Bhoite

School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur-492 010 India

Corresponding Author(s) : S.A. Bhoite

sa.bhoite10@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 7 (2016): Vol 28 Issue 7
Article Published : March 31, 2016

Abstract

Fungal infections have increased at an alarming rate. Due to the increasing development of drug resistance to antifungal agents, demand for searching novel antifungal agents is being increased. The present study was conducted to evaluate in vitro antifungal activity of mono and di phosphate esters against four fungal species i.e., Aspergillus niger, Aspergillus flavus, Alternaria redicina and Cladosporium oxysporum. Bovastin was used as a positive control to check bioactivity. Both phosphate esters showed significant growth retarding effect against selected fungal species. Di-2-methyl-5-nitroaniline phosphate has been found more sensitive as compared to mono-6-chloro-2,4-dinitroaniline phosphate. Minimum Inhibitory concentration (MIC) was determined for each fungal species. Growth inhibition at different concentrations has been calculated.

Keywords

in vitro Antifungal activity Biomass Phosphate esters Minimum inhibitory concentration

Gupta, M. K., Jadhav, S., & Bhoite, S. (2016). Synthesis and in vitro Antifungal Activity of Phosphate Esters. Asian Journal of Chemistry, 28(7), 1523–1527. https://doi.org/10.14233/ajchem.2016.19744

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References

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P. Awadhiya, Ph.D. Thesis, Synthesis, Characterization and Kinetics of Hydrolysis of Some Organic Phosphate Esters, Pt. Ravishankar Shukla University, Raipur, India (2010).
M.K. Gupta, S.K. Jadhav and S.A. Bhoite, World J. Pharm. Res., 3, 420 (2014).
M.K. Gupta, S.K. Jadhav and S.A. Bhoite, Int. J. Pharm. Pharm. Sci., 7, 267 (2015).
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References

M.M. Ford, Vet. Clin. Small. Anim, 34, 669 (2004); doi:10.1016/j.cvsm.2003.12.002.

D.L. Hawksworth, Mycol. Res., 105, 1422 (2001); doi:10.1017/S0953756201004725.

D. Jothieswari and K. Bhaskar Reddy, Int. J. Novel Trends Pharm. Sci., 4, 194 (2014).

S. Perea and T.F. Patterson, Clin. Infect. Dis., 35, 1073 (2002); doi:10.1086/344058.

H.Y. Chee and M.H. Lee, Mycobiology, 35, 241 (2007); doi:10.4489/MYCO.2007.35.4.241.

G. Sibi, R. Wadhavan, S. Singh, K. Dhananjaya, K.R. Ravikumar and H. Mallesha, Asian J. Pharm. Clin. Res., 6, 156 (2013).

R.M. Bird, A.V. Broadhurst, I.B. Duncan, M.J. Hall, R.W. Lambert and P. Wong-Kai-In, J. Antimicrob. Chemother., 18 suppl. B, 201 (1986).

C.G. Ferguson, B.I. Gorin and G.R.J. Thatcher, J. Org. Chem., 65, 1218 (2000); doi:10.1021/jo9912909.

A.M. Janiak, M. Hoffmann, M.J. Milewska and S. Milewski, Bioorg. Med. Chem., 11, 1653 (2003); doi:10.1016/S0968-0896(03)00049-X.

O.P. Pandey, S.K. Sengupta and A. Dwivedi, Electron. J. Environ. Agric. Food Chem., 4, 886 (2005).

L. Karalliedde, Anaesthesia, 54, 1073 (1999); doi:10.1046/j.1365-2044.1999.01061.x.

B. Kaboudin and F. Farjadian, Beilstein J. Org. Chem., 2, 4 (2006); doi:10.1186/1860-5397-2-4.

K.A. Hassal, Chemistry of Pesticides, Their Metabolism, Mode of Action and Uses in Crop Protection, The Macmillan Press Ltd., London, pp. 236-240 (1983).

C.R. Wagner, V.V. Iyer and E.J. McIntee, Med. Res. Rev., 20, 417 (2000); doi:10.1002/1098-1128(200011)20:6<417::AID-MED1>3.0.CO;2-Z.

P. Awadhiya, Ph.D. Thesis, Synthesis, Characterization and Kinetics of Hydrolysis of Some Organic Phosphate Esters, Pt. Ravishankar Shukla University, Raipur, India (2010).

M.K. Gupta, S.K. Jadhav and S.A. Bhoite, World J. Pharm. Res., 3, 420 (2014).

M.K. Gupta, S.K. Jadhav and S.A. Bhoite, Int. J. Pharm. Pharm. Sci., 7, 267 (2015).

A. Sen and A. Batra, Int. J. Curr. Pharm. Res., 4, 67 (2012).

C. Valgas, S.M. Souza, E.F.A. Smania and A. Smania Jr, Braz. J. Microbiol., 38, 369 (2007); doi:10.1590/S1517-83822007000200034.

R.A. Banjara, R. Aneswari, S.K. Jadhav and S.A. Bhoite, Int. J. Chem. Tech. Appl., 2, 85 (2012).

F.E. Adelowo, Int. J. Res. Rev. Appl. Sci., 12, 107 (2012).

G.S. Prasad, M. Manjunath, K.R.K.K. Reddy, O.V.S. Reddy and C.S. Reddy, ARKIVOC, 128 (2006); doi:10.3998/ark.5550190.0007.g14.

O.P. Pandey, S.K. Sengupta and A. Dwivedi, Electron. J. Environ. Agric. Food Chem., 4, 886 (2005).

J.R. Corbett, The Biochemical Mode of Action of Pesticides, Academic Press, London and New York (1974).

R. Cremlyn, Pesticides: Preparation and Mode of Action, John Wiley & Sons Ltd., pp. 134-139 (1979).

Issue

Vol. 28 No. 7 (2016): Vol 28 Issue 7

Synthesis and in vitro Antifungal Activity of Phosphate Esters

Corresponding Author(s) : S.A. Bhoite

Abstract

Keywords

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