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Isolation of Steroid Compounds from Randia malabarica (Triveng) and their Biological Activity
Corresponding Author(s) : R. Ulagi
Asian Journal of Chemistry,
Vol. 31 No. 1 (2019): Vol 31 Issue 1
Abstract
Two steroidal compounds i.e., 1-octacosanol (1) and β-sitosterol (2) were isolated from ethyl acetate fraction of Randia malabarica (Triveng). The antitumor activity of the compounds 1 and 2 were observed against A549 and HeLa using MTT assay. The isolated compounds exhibited a strong inhibitory effect on the two cancer cell lines with a significant effect of inhibition. Molecular docking studies have been performed for both the compounds, showed good inhibitory activity, thereby opening its applications to various clinical trials.
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References
D.I. Mabberley, Mabberley's Plant Book, Cambridge University Press: Cambridge (1987).
S. Nazimuddin and M. Qaiser, eds.: S.I. Ali and E. Nasir, Rubiaceae, In: Flora of Pakistan, vol. 190, pp. 1-145 (1989).
M. Del Carmen Recio, R.M. Giner, S. Manez and J.L. Ríos, Planta Med., 60, 232 (1994); https://doi.org/10.1055/s-2006-959465.
J. Sun, H. Lou, S. Dai, H. Xu, F. Zhao and K. Liu, Phytochemistry, 69, 1405 (2008); https://doi.org/10.1016/j.phytochem.2008.01.008.
J.Y. Tao, S.J. Dai, F. Zhao, J.F. Liu, W.S. Fang and K. Liu, J. Asian Nat. Prod. Res., 14, 97 (2012); https://doi.org/10.1080/10286020.2011.628839.
N. Li, L. Cao, Y. Cheng, Z.Q. Meng, Z.H. Tang, W.J. Liu, Z.-Z. Wang, G. Ding and W. Xiao, Pharm. Biol., 52, 1445 (2014); https://doi.org/10.3109/13880209.2014.895910.
H.Y. Wang, K. Liu, R.X. Wang, S.H. Qin, F.L. Wang and J.Y. Sun, Nat. Prod. Res., 29, 644 (2015a); https://doi.org/10.1080/14786419.2014.980255.
H.Y. Wang, R.X. Wang, Y.X. Zhao, K. Liu, F.L. Wang and J.Y. Sun, Chem. Biodivers., 12, 1256 (2015b); https://doi.org/10.1002/cbdv.201400289.
A.S. Nazari, S.A. Dias, W.F. da Costa, C.A. Bersani-Amado, G.J. Vidotti, M.C. de Souza and M.H. Sarragiotto, Pharm. Biol., 44, 7 (2006); https://doi.org/10.1080/13880200500496504.
J. Harborne, Phytochemical Methods; A Guide to Modern Techniques of Plant Analysis, Chapman & Hall, London, edn. 3, pp. 129-138 (1998).
S. Umadevi, G.P. Mohanta, V. Chelladurai, P.K. Manna and R. Manavalan, J. Nat. Rem., 3, 185 (2003).
J.N. Eloff, Planta Medica, 64, 711 (1998).
S. Khan, G.M. Khan, S. Mehsud, A. Rahman and F. Khan, Gomal J. Medical Sci., 2, 40 (2004).
J.P. Yuan, G.H. Wang, H. Ling, Q. Su, Y.H. Yang, Y. Song and C. Huang, World J. Gastroenterol., 10, 2731 (2004); https://doi.org/10.3748/wjg.v10.i18.2731.
L. Korrodi-Gregório, V. Soto-Cerrato, R. Vitorino, M. Fardilha and R. Pérez-Tomás, PLoS One, 11, E0165973 (2016); https://doi.org/10.1371/journal.pone.0165973.
S. Firdous, K. Khan, S. Zikr-Ur-Rehman, Z. Ali, S. Soomro, V.U. Ahmad, M. Rasheed, M.A. Mesaik and S. Faizi, Rec. Nat. Prod., 8, 51 (2014).
J. Escudero, C. Lopez, R.M. Rabanal and S. Valverde, J. Nat. Prod., 48, 128 (1985); https://doi.org/10.1021/np50037a025.
B. Muthukala, K. Sivakumari and K. Ashok, Int. J. Curr. Pharm. Res., 7, 13 (2015).