Pterocarpan Derivatives from Clinopodium urticifolium and Their Cytotoxicity
Corresponding Author(s) : Xue-Mei Gao
Asian Journal of Chemistry,
Vol. 25 No. 17 (2013): Vol 25 Issue 17 page 9672-9674
A new pterocarpan, 3(S),4(S)-3'-methoxy-4'-hydroxy-7,8,-methylenedioxylpterocarpan (1), together with four known pterocarpan derivatives (2-5), were isolated from the whole plant of Clinopodium urticifolium. The structure of 1-5 was elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compound 1 was also evaluated for its cytotoxicity against five human tumor cell lines. The results revealed that compound 1 showed high cytotoxicity against PC3 cell with IC50 values of 3.5 μM and moderate cytotoxicities with IC50 valves 5-10 μM for other four tested cell lines.
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