School of Chemistry and Materials Science, Ludong University, Yantai 264025, P.R. China ; Biology & Medicine Science and Technology Industry Park Administrative Office, Weifang Hi-Tech Development Zone, Weifang 261061, P.R. China ; College of Pharmacy, Shandong University, Jinan 250012, P.R. China
W.Q. Ma
Biology & Medicine Science and Technology Industry Park Administrative Office, Weifang Hi-Tech Development Zone, Weifang 261061, P.R. China
H.G. Chen
Biology & Medicine Science and Technology Industry Park Administrative Office, Weifang Hi-Tech Development Zone, Weifang 261061, P.R. China
C.P. Liu
School of Chemistry and Materials Science, Ludong University, Yantai 264025, P.R. China
S.G. Xu
School of Chemistry and Materials Science, Ludong University, Yantai 264025, P.R. China
X.G. Liu
School of Chemistry and Materials Science, Ludong University, Yantai 264025, P.R. China
C.N. Ji
School of Chemistry and Materials Science, Ludong University, Yantai 264025, P.R. China
X.Y. Liu
College of Pharmacy, Shandong University, Jinan 250012, P.R. China
Corresponding Author(s) : G. Liu
shdliugang@163.com
Asian Journal of Chemistry,
Vol. 25 No. 17 (2013): Vol 25 Issue 17
An efficient and facile reaction of 4-chloroquinazoline and thiols was achieved under indium mediation in water, providing a simple method for the synthesis of substituted 4-thioquinazoline compounds in good yield. The structures of the title compounds were characterized by elemental analyses as well as IR, 1H and 13C NMR spectroscopies. Preliminary biological tests showed that compound 3d exhibited good antifungal activity against Fusarium oxysporum with EC50 = 17.08 μg/mL.
Liu, G., Ma, W., Chen, H., Liu, C., Xu, S., Liu, X., … Liu, X. (2013). Synthesis of 4-Thioquinazoline Compounds in Aqueous Media Catalyzed by Indium. Asian Journal of Chemistry, 25(17), 9957–9960. https://doi.org/10.14233/ajchem.2013.15685
