Synthesis of 4-Thioquinazoline Compounds in Aqueous Media Catalyzed by Indium
Corresponding Author(s) : G. Liu
Asian Journal of Chemistry,
Vol. 25 No. 17 (2013): Vol 25 Issue 17 page 9957-9960
An efficient and facile reaction of 4-chloroquinazoline and thiols was achieved under indium mediation in water, providing a simple method for the synthesis of substituted 4-thioquinazoline compounds in good yield. The structures of the title compounds were characterized by elemental analyses as well as IR, 1H and 13C NMR spectroscopies. Preliminary biological tests showed that compound 3d exhibited good antifungal activity against Fusarium oxysporum with EC50 = 17.08 μg/mL.
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