Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, Hunan Province, P.R. China ; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang 421008, Hunan Province, P.R. China
Yonglan Feng
Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, Hunan Province, P.R. China ; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang 421008, Hunan Province, P.R. China
Zhifeng Xu
Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, Hunan Province, P.R. China ; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang 421008, Hunan Province, P.R. China
Yingqun Yang
Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, Hunan Province, P.R. China ; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang 421008, Hunan Province, P.R. China
Deping Wang
Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, Hunan Province, P.R. China ; Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, Hengyang 421008, Hunan Province, P.R. China
Corresponding Author(s) : Siping Tang
tsp00@163.com
Asian Journal of Chemistry,
Vol. 25 No. 16 (2013): Vol 25 Issue 16
A mixed-ligand copper(II) complex ((4'-ferrocenyl-2,2':6',2''-terpyridine-k3,N',N'') (1,1'-phenanthroline-k2N,N')-copper(II) bis(perchlorate)) has been synthesized. Binding interactions of the complex with calf thymus DNA (CT-DNA) were investigated by UV-visible and CD spectroscopies. Results show that the copper complex mainly adopt electrostatic attraction binding mode with DNA and the binding constant is (3.22 ± 0.05) × 103 mol-1 L. The complex shows appreciable chemical nuclease activity in the presence of ascorbic acid. The DNA cleavage by the complex were inhibited strongly in the presence of DMSO and tert-butyl alcohol, which suggests that hydroxyl radicals are reactive oxygen species for the cleavage.
Tang, S., Feng, Y., Xu, Z., Yang, Y., & Wang, D. (2013). DNA Binding and Oxidative Cleavage Studies of Mixed-ligand Copper(II) Complex. Asian Journal of Chemistry, 25(16), 9237–9240. https://doi.org/10.14233/ajchem.2013.15191
