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Vol. 25 No. 15 (2013): Vol 25 Issue 15

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2-Arylbenzofurans from the Leaves of Oriental Tobacco and Their Cytotoxicity

https://doi.org/10.14233/ajchem.2013.14716
Zhihua Liu
Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650224, P.R. China ; Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Jingmei Hang
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Wei Zhao
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Yuanxing Duan
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Yaming Wan
Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650224, P.R. China
Mingming Miao
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China

Corresponding Author(s) : Yaming Wan

ygy1110@163.com

Asian Journal of Chemistry, Vol. 25 No. 15 (2013): Vol 25 Issue 15

Abstract

Four types of 2-arylbenzofurans (1-4), including a new compound, tobarylbenzofuran A (1), were isolated from the leaves of oriental tobacco (a variety of Nicotiana tabacum L). Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The two compounds were tested for their cytotoxicity against five human tumors (NB4, A549, SHSY5Y, PC3, and MCF7) cell lines. The results showed that compound 1 showed notable inhibitory effect against SHSY5Y and MCF7 cell lines, with IC50 values of 3.5 and 1.8 μM, respectively.

Keywords

2-Arylbenzofuran Oriental tobacco Cytotoxicity Nicotiana tabacum L
Liu, Z., Hang, J., Zhao, W., Duan, Y., Wan, Y., & Miao, M. (2013). 2-Arylbenzofurans from the Leaves of Oriental Tobacco and Their Cytotoxicity. Asian Journal of Chemistry, 25(15), 8278–8280. https://doi.org/10.14233/ajchem.2013.14716
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