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Vol. 25 No. 15 (2013): Vol 25 Issue 15

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Synthesis and Anticoccidial Activities of Quinoline Carboxylate Derivatives with Methyl (E)-2-(3-methoxy)acrylate Moiety

https://doi.org/10.14233/ajchem.2013.14806
Yuan Liu
Faculty of Chemistry, Sichuan University, Chengdu 610065, P.R. China
Ya-Biao Weng
Faculty of Chemistry, Sichuan University, Chengdu 610065, P.R. China
Zhao-Bing Chen
Faculty of Chemistry, Sichuan University, Chengdu 610065, P.R. China
Yu-Liang Wang
Faculty of Chemistry, Sichuan University, Chengdu 610065, P.R. China

Corresponding Author(s) : Yu-Liang Wang

chemwang2008@163.com

Asian Journal of Chemistry, Vol. 25 No. 15 (2013): Vol 25 Issue 15

Abstract

A series of novel quinoline carboxylate derivatives with methyl (E)-2-(3-methoxy) acrylate group were designed and synthesized as anticoccidial medicines. The structures were confirmed by 1H NMR, IR and HR-MS spectra. The biological activities were primarily evaluated according to the anticoccidial index method. The results indicated that these compounds (7c, 7d, 7e, 7g) exhibited anticoccidial activities against Eimeria tenella. In particular, the anticoccidial index of 6-decyloxy-7-ethoxy-4-{6-[2-(2-methoxy-1-methoxycarbonyl-vinyl)phenoxy]pyrimidin-4-yloxy}-quinoline-3-carboxylic acid ethyl ester (7e) was 168.7, which indicated that the compound has a good anticoccidial activity.

Keywords

Quinoline carboxylate derivatives Methyl (E)-2-(3-methoxy)acrylate Anticoccidial activity Identifition Synthesis
Liu, Y., Weng, Y.-B., Chen, Z.-B., & Wang, Y.-L. (2013). Synthesis and Anticoccidial Activities of Quinoline Carboxylate Derivatives with Methyl (E)-2-(3-methoxy)acrylate Moiety. Asian Journal of Chemistry, 25(15), 8509–8512. https://doi.org/10.14233/ajchem.2013.14806
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