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Vol. 25 No. 15 (2013): Vol 25 Issue 15

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Chromones from the Flowers of Rosa rugosa and Their Cytotoxicity

https://doi.org/10.14233/ajchem.2013.14743
Liying Yang
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Jianhua Yao
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Lidan Shu
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Yanqiong Shen
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China ; Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Xuemei Gao
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Qiu-Fen Hu
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Corresponding Author(s) : Xuemei Gao

gao_xuemei@hotmail.com

Asian Journal of Chemistry, Vol. 25 No. 15 (2013): Vol 25 Issue 15

Abstract

A new chromone, 2,2-dimethyl-4-oxo-8-(2-oxopropyl)-chroman-6-yl acetate (1), together with five known chromones (2-6), were isolated from the flowers of Rosa rugosa. The structures of 1-6 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1 were evaluated for their cytotoxicity against five human tumor cell lines and it showed high cytotoxicity against A549 and MCF7 cell with IC50 values of 3.6 and 5.0 μM, respectively.

Keywords

Chromones Rosa rugosa Isolation Structure elucidation Cytotoxicity
Yang, L., Yao, J., Shu, L., Shen, Y., Gao, X., & Hu, Q.-F. (2013). Chromones from the Flowers of Rosa rugosa and Their Cytotoxicity. Asian Journal of Chemistry, 25(15), 8355–8357. https://doi.org/10.14233/ajchem.2013.14743
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