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Synthesis and Biological Evaluation of N'-(2-Hydroxybenzylidene)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazide and Its Complexes with Cu(II), Ni(II), Zn(II) and Fe(III)
Corresponding Author(s) : Muhammad Naeem Khan
Asian Journal of Chemistry,
Vol. 25 No. 15 (2013): Vol 25 Issue 15
Abstract
A new chelating agent, N’-(2-hydroxybenzylidene)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazide and its complexes with Cu(II), Ni(II), Zn(II) and Fe(III) have been synthesized and characterized on the basis of atomic absorption analysis, IR and UV-visible spectra, elemental analysis and conductance. The antibacterial, antifungal and scavenging activities of the ligands and its metal complexes have also been evaluated. In all the synthesized complexes the metal ligand ratio was found to be 1:1. Metal complexes possess antibacterial/antifungal activities better than the parent ligand while the ligand has better scavenging activity then it complexes.
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- C.M. Oliphant and G. M. Green, Am. Fam. Physician, 65, 455 (2002).
- G.Y. Lesher, E.J. Froelich, M.D. Grueth, J.H. Bailey and R.P. Brundage, J. Med. Chem., 5, 1063 (1962).
- D.E. King, R. Malone and S.H. Lilley, Am. Fam. Physician, 61, 2741 (2000).
- O.P. Pandey, Polyhedron, 5, 1587 (1986).
- E.M. Wolff, Burgers’ Medicinal Chemistry, A Wiley International Publication, San Francisco, California, Part II, edn, 4 (1979).
- A. Bacchi, A. Bonardi, M. Carcelli. P. Mazza,, P. Pelagatti, C. Pelizzi, G. Pelizzi, C. Solinas and F. Zani, J. Inorg. Biochem., 69, 101 (1998).
- A.A. Adeniyi and K.S. Patel, Synth. React. Inorg. Met.-Org. Chem., 29, 1063 (1999).
- (a) A.A. Adeniyi and K.S. Patel, Synth. React. Inorg. Met.-Org. Chem., 23, 199 (1993); (b) T.S. Ko, M.K. Park and Y.W. Ryu, Hanguk Saenghwa Hakhoechi, 23, 465 (1991).
- H.Y. Maeng, H.W. Ryn and T.S. Ko, Chungnam Kwahak Yonguchi, 21, 131 (1995).
- A. Albert, Selective Toxicity, The Physico-chemical Basis of Therapy, Chapman & Hall, London, edn. 6 (1979).
- M.N. Hughes, The Inorganic Chemistry of Biological Processes, Wiley, New York, edn. 6 (1981).
- R. Sevim and K. Güniz, Molecules, 12, 1910 (2007).
- A. Nisha, K. Rajesh and S. Chitra, J. Agric. Food Chem., 58, 3056 (2010).
- D. RuWen, W. JiGui and N.C. Zhong, Synth. React. Inorg. Met.-Org. Chem., 22, 1295 (1993).
- U.N. Mahajan and D.D. Phcog, Mag., 4 (2008).
- A.W. Bauer, W.M. Kirby, J. Sherris and M. Turk, Am. J. Clin. Pathol.,45, 493 (1966).
- K. Angela, L.D. Mariana and G.S. Dianu, Anal. Universit. BucurestiSeria Chimie, 33 (2002).
- L. El-Sayed and M.F. Iskander, J. Inorg. Nucl. Chem., 33, 435 (1971)
References
C.M. Oliphant and G. M. Green, Am. Fam. Physician, 65, 455 (2002).
G.Y. Lesher, E.J. Froelich, M.D. Grueth, J.H. Bailey and R.P. Brundage, J. Med. Chem., 5, 1063 (1962).
D.E. King, R. Malone and S.H. Lilley, Am. Fam. Physician, 61, 2741 (2000).
O.P. Pandey, Polyhedron, 5, 1587 (1986).
E.M. Wolff, Burgers’ Medicinal Chemistry, A Wiley International Publication, San Francisco, California, Part II, edn, 4 (1979).
A. Bacchi, A. Bonardi, M. Carcelli. P. Mazza,, P. Pelagatti, C. Pelizzi, G. Pelizzi, C. Solinas and F. Zani, J. Inorg. Biochem., 69, 101 (1998).
A.A. Adeniyi and K.S. Patel, Synth. React. Inorg. Met.-Org. Chem., 29, 1063 (1999).
(a) A.A. Adeniyi and K.S. Patel, Synth. React. Inorg. Met.-Org. Chem., 23, 199 (1993); (b) T.S. Ko, M.K. Park and Y.W. Ryu, Hanguk Saenghwa Hakhoechi, 23, 465 (1991).
H.Y. Maeng, H.W. Ryn and T.S. Ko, Chungnam Kwahak Yonguchi, 21, 131 (1995).
A. Albert, Selective Toxicity, The Physico-chemical Basis of Therapy, Chapman & Hall, London, edn. 6 (1979).
M.N. Hughes, The Inorganic Chemistry of Biological Processes, Wiley, New York, edn. 6 (1981).
R. Sevim and K. Güniz, Molecules, 12, 1910 (2007).
A. Nisha, K. Rajesh and S. Chitra, J. Agric. Food Chem., 58, 3056 (2010).
D. RuWen, W. JiGui and N.C. Zhong, Synth. React. Inorg. Met.-Org. Chem., 22, 1295 (1993).
U.N. Mahajan and D.D. Phcog, Mag., 4 (2008).
A.W. Bauer, W.M. Kirby, J. Sherris and M. Turk, Am. J. Clin. Pathol.,45, 493 (1966).
K. Angela, L.D. Mariana and G.S. Dianu, Anal. Universit. BucurestiSeria Chimie, 33 (2002).
L. El-Sayed and M.F. Iskander, J. Inorg. Nucl. Chem., 33, 435 (1971)