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Vol. 25 No. 15 (2013): Vol 25 Issue 15

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Non-Acidic Mediated Friedel-Craft Reaction of Thiophene Using EtAlCl2

https://doi.org/10.14233/ajchem.2013.15607
Halil Unver
Department of Chemistry, Kirikkale University, 71450 Kirikkale, Turkey
Mutluhan Biyikoglu
Department of Chemistry, Kirikkale University, 71450 Kirikkale, Turkey
Adnan Bulut
Department of Chemistry, Kirikkale University, 71450 Kirikkale, Turkey

Corresponding Author(s) : Adnan Bulut

adnnblt@kku.edu.tr

Asian Journal of Chemistry, Vol. 25 No. 15 (2013): Vol 25 Issue 15

Abstract

Since alkyl Lewis acids are Brønsted bases, they give a non-acidic reaction media. In this context, acylation of thiophene is investigated in the presence of EtAlCl2 and non-acidic media. Besides 8 examples of thiophene, one example for pyrrole is synthesized in moderate to high yields (up to 99 %).

Keywords

Thiophene Acylation Alkyl Lewis acid Electrophilic aromatic substitution
Unver, H., Biyikoglu, M., & Bulut, A. (2013). Non-Acidic Mediated Friedel-Craft Reaction of Thiophene Using EtAlCl2. Asian Journal of Chemistry, 25(15), 8772–8774. https://doi.org/10.14233/ajchem.2013.15607
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