Issue

Vol. 25 No. 15 (2013): Vol 25 Issue 15

Copyright (c) 2013 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis of Novel Schiff Bases by Microwave Irradiation and Their in vitro Antibacterial Activity

https://doi.org/10.14233/ajchem.2013.14878
Salman A. Khan
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Kingdom of Saudi Arabia
Abdullah M. Asiri
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Kingdom of Saudi Arabia ; Center of Excellence for Advanced Materials Research, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Kingdom of Saudi Arabia
Aftab Aslam Parwaz Khan
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Kingdom of Saudi Arabia ; Center of Excellence for Advanced Materials Research, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Kingdom of Saudi Arabia
Khalid Ali Khan
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Kingdom of Saudi Arabia
Mohie A.M. Zayed
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Kingdom of Saudi Arabia

Corresponding Author(s) : Salman A. Khan

sahmad_phd@yahoo.co.in

Asian Journal of Chemistry, Vol. 25 No. 15 (2013): Vol 25 Issue 15

Abstract

A series of thiophene-3-carbonitrile contaning schiff bases were synthesized, characterized by the reaction of 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carbonitrile and corresponding active aldehyde under microwave irradiation and screened for their antibacterial activities. The structure of synthesized compounds were established by spectroscopic (FT-IR, 1H NMR, 13C NMR, Mass) and elemental analyses. The antibacterial activity of these compounds were first tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria and then the minimum inhibitory concentration was determined with the reference of standard drug chloramphenicol. The results showed that compound 6 is better at inhibiting the growth as compared to chloramphenicol against both types of the bacteria (gram-positive and gram-negative).

Keywords

Schiff bases Microwave Chloramphenicol Antibacterial activity
A. Khan, S., M. Asiri, A., Aslam Parwaz Khan, A., Ali Khan, K., & A.M. Zayed, M. (2013). Synthesis of Novel Schiff Bases by Microwave Irradiation and Their in vitro Antibacterial Activity. Asian Journal of Chemistry, 25(15), 8643–8646. https://doi.org/10.14233/ajchem.2013.14878
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. F. Qadri, A.M. Svennerholm, A.S.G. Faruque and R.B. Sack, Clin. Microbiol. Rev., 18, 465 (2005).
  2. W. Zhang, E.M. Berberoy, J. Freeling, D. He, R.A. Moxley and D.H. Francis, Infec. Immun., 74, 3107 (2006).
  3. C.C. Butler, S. Hillier, Z. Roberts, F. Dunstan,A. Howard and S. Palmer, Br. J. Gen. Pract., 56, 686 (2006).
  4. S.A. Puerto, G.J. Fernandez, L.J. Castillo, M. Jose, S. Pinoa and P.G. Anguloa, Diag. Microbiol. Infect. Dis., 42, 1513 (2006).
  5. H. Schiff, Justus Liebigs Ann. Chem., 131, 118 (1864).
  6. M.Y. Khuhawar, M.A. Mughal and A.H. Channar, Eur. Polym. J., 40, 805 (2004).
  7. K. Nejati, Z. Rezvani and B. Massoumi, Dyes Pigments, 75, 653 (2007).
  8. S. Alexander, V. Udayakumar and V. Gayathri, J. Mol. Catal. A., 314, 21 (2009).
  9. R. Karvembu, S. Hemalatha, R. Prabhakaran and K. Natarajan,Inorg. Chem. Comm., 6, 486 (2003).
  10. M.W. Sabaa, R.R. Mohamed and E.H. Oraby, Eur. Polym. J., 45, 3072 (2009).
  11. Z.H. Chohan, S.H. Sumrra, M.H. Youssoufi and T.B. Hadda, Eur. J. Med., 45, 2739 (2010).
  12. T. Rosu, E. Pahontu, C. Maxim, R. Georgescu, N. Stanica, G.L. Almajan and A. Gulea, Polyhedron, 29, 757 (2010).
  13. N.B. Patel and J.C. Patel, Arabian J. Chem., 4, 403 (2011).
  14. L. Cheng, J. Tang, H. Luo, X. Jin, F. Dai, J. Yang, Y. Qian, X. Li and B. Zhou, Bioorg. Med. Chem. Lett., 20, 2417 (2010).
  15. A. Geronikaki, D. Hadjipavlou-Litina and M. Amourgianou, IL Farmaco, 58, 489 (2003).
  16. M. Kritsanida,A. Mouroutsou, P. Marakos, N. Pouli, S. PapakonstantinouGaroufalias, C. Pannecouque, M. Witvrouw and E. De Clercq, IL Farmaco, 57, 253 (2002).
  17. S.K.S. Hazari, J. Kopf, D. Palit, S. Rakshit and D. Rehder, Inorg. Chim. Acta, 362, 1343 (2009).
  18. A. Karakas, H. Unver and A. Elmali, J. Mol. Struct., 712, 117 (2004).
  19. L. Kong, Z. Li, T. Okamura, G. Ma, Q. Chu, H. Zhu, S. Tang, W. Sun and N. Ueyama, Chem. Phys. Lett., 416, 176 (2005).
  20. I. Kaya, M. Yildirim and A. Avc, Synth. Metals, 160, 911 (2010).
  21. N.A. Negm, Y.M. Elkholy, M.K. Zahran and S.M. Tawfik, Corr. Sci., 52, 3523 (2010).
  22. J.G. Ghogare, S.V. Bhandari, K.G. Bothara,A.R. Madgulkar, G.A. Parashar, B.G. Sonawane and P.R. Inamdar, Eur. J. Med. Chem., 45, 857 (2010).
  23. G. Zapata-Sudo, L.B. Pontes, D. Gabriel, T.C.F. Mendes, N.M. Ribeiro, A.C. Pinto, M.M. Trachez and R.T. Sudo, Pharmacol. Biochem. Behav., 86, 678 (2010).
  24. S.V. Bhandari, K.G. Bothara, M.K. Raut, A.A. Patil, A.P. Sarkate and V.J. Mokale, Bioorg. Med. Chem., 16, 678 (2008).
  25. Z. Li, Z. Gu, K. Yin, R. Zhang, Q. Deng and J. Xiang, Eur. J. Med. Chem., 44, 4716 (2009).
  26. S.K. Bharti, G. Nath, R. Tilak and S.K. Singh, Eur. J. Med. Chem., 45, 651 (2010).
  27. B.S. Creaven, B. Duff, D.A. Egan, K. Kavanagh, G. Rosair, V.R. Thangella and M. Walsh, Inorg. Chim. Acta, 363, 4048 (2010).
  28. M.M. Aly, Y.A. Mohamed, K.A.M. El-Bayouki, W.M. Basyouni and S.Y. Abbas, Eur. J. Med. Chem., 45, 3365 (2010).
  29. K.M. Amin, M.M. Kamel, M.M. Anwar, M. Khedr and Y.M. Syam, Eur. J. Med. Chem., 45, 2117 (2010).
  30. M. Sonmez, M. Celebi, Y. Yardim and Z. Senturk, Eur. J. Med. Chem., 45, 4215 (2010).
  31. H.M. Marwani, A.M. Asir and S.A. Khan, Russ. J. Bioorg. Chem., 38, 533 (2012).
  32. A.M. Asiri and S.A. Khan, Molecules, 15, 4784 (2010)
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0