Issue

Vol. 25 No. 15 (2013): Vol 25 Issue 15

Copyright (c) 2013 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Inhibitory Activities of Griseofulvin and Its Analogues against Phytopathogenic Fungi

https://doi.org/10.14233/ajchem.2013.15664
Yu-Jing Zhu
Agricultural Bio-Resources Institute, Fujian Academy of Agricultural Sciences, Fuzhou 350003, P.R. China
Zhi-Zhen Pan
Agricultural Bio-Resources Institute, Fujian Academy of Agricultural Sciences, Fuzhou 350003, P.R. China
Xiao-Jie Yu
Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of Environment and Ecology, School of Life Science, Xiamen University, Xiamen 361005, P.R. China
Zhi-Cong Li
Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of Environment and Ecology, School of Life Science, Xiamen University, Xiamen 361005, P.R. China
Ming-Xing Su
Agricultural Bio-Resources Institute, Fujian Academy of Agricultural Sciences, Fuzhou 350003, P.R. China
Jian-Zhong Huang
Engineering Research Center of Industrial Microbiology, Ministry of Education, Fujian Normal University, Fuzhou 350108, P.R. China
Song-Gang Wu
Engineering Research Center of Industrial Microbiology, Ministry of Education, Fujian Normal University, Fuzhou 350108, P.R. China
Qing-Xi Chen
Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of Environment and Ecology, School of Life Science, Xiamen University, Xiamen 361005, P.R. China
Bo Liu
Agricultural Bio-Resources Institute, Fujian Academy of Agricultural Sciences, Fuzhou 350003, P.R. China

Corresponding Author(s) : Qing-Xi Chen

chenqx@xmu.edu.cn

Asian Journal of Chemistry, Vol. 25 No. 15 (2013): Vol 25 Issue 15

Abstract

The antifungal activity of griseofulvin was evaluated against phytopathogenic fungi including Fusarium moniliforme, Fusarium solani, Fusarium oxysporum and Colletotrichum truncatum. The greenhouse test was also made to evaluate the control efficiency of griseofulvin to eggplant powdery mildew. The results indicated griseofulvin could not only obviously inhibit fungi in laboratory experiments but efficiently control eggplant powdery mildew in greenhouse test. Subsequently, five griseofulvin analogues were synthesized and evaluated for antifungal activities against the four fungi. The results showed that these compounds performed significantly different activities in comparison with griseofulvin. The inhibition mechanism and bioavailability of active analogues were taken to expound their different performance and relations of structure and activity. The solubility in different solvents of analogues and griseofulvin was roughly evaluated and compared.

Keywords

Griseofulvin Antifungal activity Greenhouse test Analogues Solubility comparison
Zhu, Y.-J., Pan, Z.-Z., Yu, X.-J., Li, Z.-C., Su, M.-X., Huang, J.-Z., … Liu, B. (2013). Inhibitory Activities of Griseofulvin and Its Analogues against Phytopathogenic Fungi. Asian Journal of Chemistry, 25(15), 8788–8792. https://doi.org/10.14233/ajchem.2013.15664
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. A.E. Oxford, H. Raistrick and P. Simonart, Biochem. J., 33, 240 (1939).
  2. H.T. Behrman, I.I. Lubowe, E.H. Mandel and J.L. Morse, Antibiot. Ann., 7, 701 (1960).
  3. A. Del Palacio-Hernanz, S.L. Gomez and L. González, Clin. Exp. Dermatol., 15, 210 (1990).
  4. A. Kappas and S.G. Georgopoulos, J. Bacteriol., 119, 334 (1974).
  5. F.S. Corrêa Biancalana, P.F.G. Telles, L. Lyra and A.Z. Schreiber, Mycoses, 51, 313 (2008).
  6. H. Blank, J.R. Frank, W.W. Bruce, M.F. Engel, J.G. Smith and N. Zaias, Arch. Dermatol., 79, 259 (1959).
  7. A.H. Andrews and J. Edwardson, Vet. Rec., 108, 498 (1981).
  8. S. Knasmüller, W. Parzefall, C. Helma, F. Kassie, S. Ecker and R. SchulteHermann, Crit. Rev. Toxicol., 27, 495 (1997).
  9. Y. Corvis, W. Barzyk, G. Brezesinski, N. Mrabet, M. Badis, S. Hecht and E. Rogalska, Langmuir, 22, 7701 (2006).
  10. B. Rebacz, T.O. Larsen, M.H. Clausen, M.H. Rønnest, H. Löffler, A.D. Ho and A. Kramer, Cancer Res., 67, 6342 (2007).
  11. M.H. Rønnest, B. Rebacz, L. Markworth,A.H. Terp, T.O. Larsen,A. Kramer and M.H. Clausen, J. Med. Chem., 52, 3342 (2009).
  12. A. Feinstein, E. Sofer, H. Trau and M. Schewach-Millet, J. Am. Acad. Dermatol., 10, 915 (1984).
  13. M.H.A. Rustin, C.B. Bunker, P.M. Dowd and T.W. Robinson, Br. J. Dermatol., 120, 455 (1989).
  14. P. Kolachana and M.T. Smith, Mutat. Res./Gen. Tox., 322, 151 (1994).
  15. S.H. Crowdy, J.F. Grove and P. McCloskey, Biochem. J., 72, 241 (1959).
  16. A. Rhodes, Antibiotics in Agriculture, Butterworth, London, pp. 101- 121 (1962).
  17. R. Crosse, R. McWilliam and A. Rhodes, J. Gen. Microbiol., 34, 51 (1964).
  18. K. Byoung-Seob, O. Takayuki and Y. Kyohei, Agric. Biol. Chem., 54, 2199 (1990).
  19. H. Newman, J. Org. Chem., 35, 3990 (1970).
  20. T. Muhizi, V. Coma and S. Grelier, Carbohydr. Res., 343, 2369 (2008).
  21. T. Muhizi, S. Grelier and V. Coma, J. Agric. Food. Chem., 57, 11092 (2009).
  22. M. Mota,A.K. Campos and J.V. Araújo,Braz. J. Microbiol., 34, 157 (2003).
  23. Q.Y. Tang and M.G. Feng, Science Press., Beijing (2002).
  24. K. Gull and A.P.J. Trinci, Nature, 244, 292 (1973).
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 0