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Vol. 25 No. 15 (2013): Vol 25 Issue 15

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Facile Synthesis and Biological Evaluation of Substituted 5-(1H-Indol-3-ylmethylene) pyrimidine-2,4,6-trione Derivatives Using L-Tyrosine in Aqueous Medium

https://doi.org/10.14233/ajchem.2013.15364
G. Thirupathi
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, College of Engineering, Kukatpally, Hyderabad-500 085, India
P.K. Dubey
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, College of Engineering, Kukatpally, Hyderabad-500 085, India
Y. Bharathi Kumari
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, College of Engineering, Kukatpally, Hyderabad-500 085, India

Corresponding Author(s) : G. Thirupathi

thirupathigjntuh@gmail.com

Asian Journal of Chemistry, Vol. 25 No. 15 (2013): Vol 25 Issue 15

Abstract

L-Tyrosine as an efficient catalyst for the Knoevenagel condensation of substituted indole-3-aldehydes 1(a-d), N-methyl indole-3-aldehydes 4(a-d), N-ethyl indole-3-aldehydes 6(a-d) with barbituric acid (2) containing cyclic active methylene group to produce 3(a-d), 5(a-d) and 7(a-d), respectively in water at room temperature for 10 min. The antimicrobial activities of 3(a-d), 5(a-d) and 7(a-d) have been studied.

Keywords

Antibacterial activities Antifungal activities Indole-3-aldehyde Barbituric acid L-Tyrosine Knoevenagel reaction
Thirupathi, G., Dubey, P., & Bharathi Kumari, Y. (2013). Facile Synthesis and Biological Evaluation of Substituted 5-(1H-Indol-3-ylmethylene) pyrimidine-2,4,6-trione Derivatives Using L-Tyrosine in Aqueous Medium. Asian Journal of Chemistry, 25(15), 8741–8748. https://doi.org/10.14233/ajchem.2013.15364
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