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Vol. 25 No. 15 (2013): Vol 25 Issue 15

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Systemic Delivery of Allium cepa L. var agrogatum Don Flavonoid-Rich Extract via the Percutaneous Route Using a Microemulsion System

https://doi.org/10.14233/ajchem.2013.15342
Zhiying Ding
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, P.R. China
Min Wu
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, P.R. China ; First Hospital, Jilin University, Changchun 130021, P.R. China
Yue Zhang
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, P.R. China
Yufang He
Jilin Academy of Chinese Medicine Sciences, Changchun 130012 , P.R. China
Jing Wang
First Hospital, Jilin University, Changchun 130021, P.R. China
Qiushi Guo
First Hospital, Jilin University, Changchun 130021, P.R. China
Bingren Zhang
College of Instrumentation and Electrical Engineering, Jilin University, 938 Ximinzhu Street, Chaoyang District, Changchun City, Jilin Province, P.R. China

Corresponding Author(s) : Bingren Zhang

zbr@jlu.edu.cn

Asian Journal of Chemistry, Vol. 25 No. 15 (2013): Vol 25 Issue 15

Abstract

The present study evaluated the potential of an oil-in-water (o/w) microemulsion to serve as a topical carrier for the percutaneous absorption of Allium cepa L. var agrogatum Don flavonoid-rich extract. The percutaneous absorption of Allium cepa L. var agrogatum Don flavonoid-rich extract from an o/w microemulsion preparation was evaluated in vivo using hairless rats. Based on the distribution in vivo and the localization of Allium cepa L. var agrogatum Don flavonoid-rich extract in the skin, it has been concluded that the systemic delivery of Allium cepa L. var agrogatum Don flavonoid-rich extract via the percutaneous route is the result of the encapsulation of Allium cepa L. var agrogatum Don flavonoid-rich extract within the nano-droplet clusters of an o/w microemulsion. In the present study, microemulsion also exhibits distinct differences in the concentration profile between tissues. Fluorescence images of the skin were taken 10 min and 7 h after application. The fluorescence signal of Allium cepa L. var agrogatum Don flavonoid-rich extract within the skin indicates that the penetration pathway of Allium cepa L. var agrogatum Don flavonoid-rich extract from the o/w microemulsion includes both the follicular and transcellular routes.

Keywords

Microemulsion Percutaneous absorption Transcellular Allium cepa L var agrogatum Don flavonoid-rich extract
Ding, Z., Wu, M., Zhang, Y., He, Y., Wang, J., Guo, Q., & Zhang, B. (2013). Systemic Delivery of Allium cepa L. var agrogatum Don Flavonoid-Rich Extract via the Percutaneous Route Using a Microemulsion System. Asian Journal of Chemistry, 25(15), 8727–8731. https://doi.org/10.14233/ajchem.2013.15342
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