Microwave-Assistant Synthesis, Crystal Structure and Fungicidal Activity of 3-Chloro-2-hydrazinylpyridine

Wei Ke; Na-Bo Sun; Hong-Ke Wu

doi:10.14233/ajchem.2013.15329

Issue

Vol. 25 No. 15 (2013): Vol 25 Issue 15

Issue Published : September 15, 2013

This work is licensed under a Creative Commons Attribution 4.0 International License.

Microwave-Assistant Synthesis, Crystal Structure and Fungicidal Activity of 3-Chloro-2-hydrazinylpyridine

https://doi.org/10.14233/ajchem.2013.15329

Wei Ke

College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, Zhejiang Pronvince, P.R. China

Na-Bo Sun

College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, Zhejiang Pronvince, P.R. China

Hong-Ke Wu

College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, Zhejiang Province, P.R. China

Corresponding Author(s) : Hong-Ke Wu

wuhk910@gmail.com

Asian Journal of Chemistry, Vol. 25 No. 15 (2013): Vol 25 Issue 15
Article Published : September 12, 2013

Abstract

A pyridine derivative i.e., 3-chloro-2-hydrazinylpyridine (C₅H₆N₃Cl) was synthesized under microwave irradiation and its structure was studied by X-ray diffraction and ¹H NMR. The crystals are monoclinic, space group p2₁/c with a = 11.6276 (14), b = 3.8924 (5), c = 13.9558 (17) Å, a = 90.00, b = 103.447 (6), g = 90.00º, V = 614.31(13)Å³, Z = 4, F₍₀₀₀₎ = 296, D_c = 1.552g/cm³, μ = 0.52 cm^-1, the final R = 0.0623 and wR = 0.1897. A total of 7008 reflections were collected, of which 1406 were independent (R_int = 0.0544). The fungicidal activity of this compound was also studied.

Keywords

Microwave assistant synthesis Crystal structure Biological activity

Ke, W., Sun, N.-B., & Wu, H.-K. (2013). Microwave-Assistant Synthesis, Crystal Structure and Fungicidal Activity of 3-Chloro-2-hydrazinylpyridine. Asian Journal of Chemistry, 25(15), 8708–8710. https://doi.org/10.14233/ajchem.2013.15329

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References

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(a). X.H. Liu, C.X. Tan and J.Q. Weng, Asian J. Chem., 23, 4064 (2011); (b). X.H. Liu, C.X. Tan and J.Q. Weng, Phosphorus Sulfur Silicon Rel. Elem., 186, 552 (2011); (c). X.H. Liu, J.Q. Weng, C.X. Tan, L. Pan, B.L. Wang and Z.M. Li, Asian J. Chem., 23, 4031 (2011); (d). C.X. Tan, Y.X. Shi, J.Q. Weng, X. H. Liu, B.J. Li and W.G. Zhao, Lett. Drug Des. Discov., 9, 431 (2012); (e). J.Y. Tong, Y.X. Shi, X.H. Liu, N.B. Sun and B.J. Li, Chin. J. Org. Chem., 32, 2373 (2012); (f). X.H. Liu, W.G. Zhao, B.L. Wang and Z.M. Li, Res. Chem. Intermed., 38, 1999 (2012); (g). N.N. Su, Y. Li, S.J. Yu X. Zhang, X.H. Liu and W.G. Zhao, Res. Chem. Intermed., 39, 759(2012); (h. X.H.Liu, L. Pan, Y. Ma, J.Q. Weng, C.X. Tan, Y.H. Li, Y.X. Shi, B.J. Li, Z.M. Li and Y.G. Zhang, Chem. Biol. Drug Des., 78, 689 (2011); (i). X.H. Liu, J.Q. Weng, B.L. Wang, Y.H. Li, C.X. Tan and Z.M. Li, Res. Chem. Intermed., DOI: 10.1007/s11164-013-1113-4 (2013); (j) J.Y. Tong, N.B. Sun and H.K. Wu, J. Chem. Soc. Pak., 34, 1300 (2012); (k). N.B. Sun, J.Z. Jin, C. Lei and W. Ke, Asian J. Chem., 25, 4067(2013).

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A.A. Salarian, A. Asadi-Eskandar, A. Sakhteman and K. Abdi, Asian J. Chem., 25, 1275 (2013).

(a) S.V. Rao, D. Komali, S.K. Ameer, S.D.V.V.S.S. Raju and K.N. Reddy, Asian J. Chem., 24, 3203 (2012); (b) S. Karabocek, E. Senses, N. Karabocek and S.A. Karaoglu, Asian J. Chem., 24, 188 (2012).

M.E.B. Rao and V.G. Rajurkar, Asian J. Chem., 23, 2648 (2011).

(a) B. Kumar, K.K. Prasad and S.K. Srivastava, Asian J. Chem., 23, 1680 (2011); (b) S. Benhammadi, A.A. Othman, A. Derdour and A. Mami, Asian J. Chem., 22, 5535 (2010); (c) V. Judge, B. Narasimhan, M. Ahuja, D. Sriram and P. Yogeeswari, Lett. Drug Des. Discov., 8, 792 (2011).

F.A. Bassyouni, H.A. Tawfik, A.M. Soliman and M.A. Rehim, Res. Chem. Intermed., 38, 1291(2012).

E.M. El-Telbani, S.M. Ghanem, F.A. El-Essawy and A.F. El-Sayed, Lett. Drug Des. Discov., 8, 822 (2011).

Y.B. Wang, Haiquan, W.L. Huang, H.B. Zhang and J.P. Zhou, Lett. Drug Des. Discov., 8, 500 (2011)

Issue

Vol. 25 No. 15 (2013): Vol 25 Issue 15

Microwave-Assistant Synthesis, Crystal Structure and Fungicidal Activity of 3-Chloro-2-hydrazinylpyridine

Corresponding Author(s) : Hong-Ke Wu

Abstract

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