Synthesis and Antibacterial Activity of Pyrazolo[1,5-a]quinazoline-3-carbonitriles

Abstract

A method for the synthesis of 4,5,6,7,8,9-hexahydro-5-arylpyrazolo[1,5-a]quinazoline-3-carbonitriles was developed. 5-Aminopyrazole-4-carbonitrile when reacted with aromatic aldehydes gives the schiff's base which on cyclization with cyclohexanone in the presence of glacial acetic acid produces a series of title compounds. The synthesized compounds were characterized through elemental analysis and spectroscopic techniques (FTIR, ¹H NMR and MS). The antibacterial activity of these compounds was also tested against six different bacterial strains by agar plate disc method.