College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, P.R. China ; Faculty of Engineering and the Environment, University of Southampton, Southampton SO17 1BJ, UK
Yi Wang
College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, P.R. China
Ye-Fei Nan
College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, P.R. China
Xun-Yu Xiong
College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, P.R. China
Qing Pan
Department of Pharmacy, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, P.R. China
Xun-Li Zhang
College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, P.R. China ; Faculty of Engineering and the Environment, University of Southampton, Southampton SO17 1BJ, UK
Corresponding Author(s) : Xun-Li Zhang
xlzhang@xsyu.edu.cn
Asian Journal of Chemistry,
Vol. 25 No. 13 (2013): Vol 25 Issue 13
A new method has been developed for the synthesis of b-(3,4-dihydroxyphenyl)lactic acid, an active ingredient for the treatment of myocardial ischemia. Pd/C catalysts were used in the key reduction reaction to replace the traditionally used toxic Zn/Hg catalysts. A significantly high product yield of 99.7 % was obtained under the optimal reaction conditions, through the use of orthogonal experimental design, when reaction temperature, catalyst (5 % Pd/C) amount and pressure were 60 ºC, 20 wt % and 1.0 MPa, respectively.
