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Vol. 28 No. 5 (2016): Vol 28 Issue 5

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Synthesis, Characterization and Antibacterial Activity of Some Prop-2-ynyl 2-[{2-((E)-(benzoylhydrazono)methyl)phenyl}sulfanyl]acetate Derivatives

https://doi.org/10.14233/ajchem.2016.19584
R. Adinarayana Reddy
Department of Chemistry, Government Degree College for Men (A), Kadapa-516 004, India
V. Krishna Reddy
Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515 003, India
B. Ram
Green Evolution Laboratories, Wangapally Village, Nalgonda-500 085, India
B. Balram
Green Evolution Laboratories, Wangapally Village, Nalgonda-500 085, India

Corresponding Author(s) : R. Adinarayana Reddy

adirp2@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 5 (2016): Vol 28 Issue 5

Abstract

A series of eleven new hydrazide-hydrazone derivatives (7a-7k) have been synthesized from prop-2-ynyl-2-(2-formylphenylthio)acetate (5) which was derived by condensation of 2-mercaptobenzaldehyde (1) with prop-2-ynyl-2-bromoacetate (4). Structures of synthesized compounds have been established by spectral analysis. The synthesized prop-2-ynyl 2-((2-((E)-(benzoylhydrazono)methyl)phenyl)-sulfanyl)acetate derivatives (7a-7k) were tested against Gram-positive strains of (i) Staphylococcus aureus (MTCC 96) and (ii) Streptococcus pyogenes (MTCC 442) and Gram-negative strains of (iii) Escherichia coli (MTCC 443) and (iv) Pseudomonas aeruginosa (MTCC 424) using agar well diffusion method. Norfloxacin was used as the reference antibacterial drug. Compounds 7i (R = 4-SO2Me) and 7j (R = 2,5-difluoro) showed excellent activity with zone of inhibition 29 and 30 mm, respectively, while the compounds 7h (R = 4-CN) and 7k (R = 3-NO2) showed good antibacterial activity with zone of inhibition 23 and 22 mm, respectively against E. coli. The compounds showed similar trends against P. aerugenosa, S. aureus and S. pyogenes.

Keywords

Antibacterial activity Acteylene compounds Hydrazones 2-Mercaptobenzaldehyde Propargyl alcohol
Reddy, R. A., Reddy, V. K., Ram, B., & Balram, B. (2016). Synthesis, Characterization and Antibacterial Activity of Some Prop-2-ynyl 2-[{2-((E)-(benzoylhydrazono)methyl)phenyl}sulfanyl]acetate Derivatives. Asian Journal of Chemistry, 28(5), 1054–1058. https://doi.org/10.14233/ajchem.2016.19584
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