Enantioselective Alkynylation of Trifluoromethyl Ketones Catalyzed by Chiral Schiff Bases

Vasudevan Dhayalan; Ryo Murakami; Masahiko Hayashi

doi:10.14233/ajchem.2013.14943

Issue

Vol. 25 No. 13 (2013): Vol 25 Issue 13

Issue Published : 17 July 2013

This work is licensed under a Creative Commons Attribution 4.0 International License.

Enantioselective Alkynylation of Trifluoromethyl Ketones Catalyzed by Chiral Schiff Bases

https://doi.org/10.14233/ajchem.2013.14943

Vasudevan Dhayalan

Department of Chemistry, Graduate School of Science, Kobe University. 1-1 Rokkodai-cho, Nada-ku, Hyogo 657-8501, Japan

Ryo Murakami

Department of Chemistry, Graduate School of Science, Kobe University. 1-1 Rokkodai-cho, Nada-ku, Hyogo 657-8501, Japan

Masahiko Hayashi

Department of Chemistry, Graduate School of Science, Kobe University. 1-1 Rokkodai-cho, Nada-ku, Hyogo 657-8501, Japan

Corresponding Author(s) : Masahiko Hayashi

mhayashi@kobe-u.ac.jp

Asian Journal of Chemistry, Vol. 25 No. 13 (2013): Vol 25 Issue 13
Article Published : 22 July 2013

Abstract

Enantioselective alkynylation of trifluoromethyl ketones catalyzed by chiral Schiff bases in the presence of Me₂Zn afforded the corresponding trifluoroalkynyl alcohols in up to 66 % ee.

Keywords

Alkynylation Asymmetric catalysis Schiff base Enantioselectivity

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Dhayalan, V.; Murakami, R.; Hayashi, M. Enantioselective Alkynylation of Trifluoromethyl Ketones Catalyzed by Chiral Schiff Bases. ajc 2013, 25, 7505-7508.