Synthesis, Crystal Structure and DNA-Binding of Lanthanum Complex with Schiff Base Derived from o-Vanillin and p-Toluidine

Abstract

A new complex [La(NO₃)₃(C₂H₅OH)(C₁₅H₁₅NO₂)₂] was synthesized from lanthanum nitrate and Schiff base (C₁₅H₁₅NO₂, derived form o-vanillin and p-toluidine) by refluxing in ethanol. It's crystal structure was determined by single crystal X-ray diffraction method. The complex is crystallize in triclinic, space group P-1, with a = 0.79851(3) nm, b = 1.47473(5) nm, c = 1.63872(6) nm, a = 73.546(2)º, b = 86.769(2)º, g = 79.767(2)º, V = 1.82123(1) nm³, Z = 2, M_r = 852.56, F(000) = 1862, Dc = 1.555 g cm^-3, μ(M₀K_a) = 1.056 mm^-1. It turned out that six oxygen atoms from three nirtate anions, one oxygen atom in ethanol and two phenolate oxygen atoms from two Schiff base ligands coordinate to La(III), forming a 9-coordination distorted monocapped square prism geometry. In addition, DNA-binding of the complex was studied by EtBr fluoescent probe and the results show that the complex interact with DNA by intercalative mode. CCDC:878971.