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Vol. 28 No. 5 (2016): Vol 28 Issue 5

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in vitro Haemolytic and Thrombolytic Activities of Launaea cornuta

https://doi.org/10.14233/ajchem.2016.19591
Z. Khan
Institute of Chemical Sciences, Gomal University D.I. Khan, Khyber Pakhtunkhwa, Pakistan
Mohammad Iqbal
Department of Otolaryngology, Head & Neck Surgery, Bannu Medical College Bannu, Khyber Pakhtunkhwa, Pakistan
W. Ahmed
Department of Biotechnology, Faculty of Biological Sciences, University of Science & Technology, Bannu, Khyber Pakhtunkhwa, Pakistan
M.U. Khayam
Department of Pharmacy, Kohat University of Science & Technology, Kohat, Khyber Pakhtunkhwa, Pakistan
S. Kiran
Institute of Chemical Sciences, Gomal University D.I. Khan, Khyber Pakhtunkhwa, Pakistan
A. Subhan
Institute of Chemical Sciences, Gomal University D.I. Khan, Khyber Pakhtunkhwa, Pakistan
R. Yasmine
Institute of Chemical Sciences, Gomal University D.I. Khan, Khyber Pakhtunkhwa, Pakistan

Corresponding Author(s) : W. Ahmed

waseem_bnu57@yahoo.com

Asian Journal of Chemistry, Vol. 28 No. 5 (2016): Vol 28 Issue 5

Abstract

Launaea cornuta or bitter lettuce is a herbaceous perennial plant having a creeping root system that produces a basal rosette of leaves with a central stem that is usually up to 1 m tall, occasionally to 1.5 m. As a result of spread by rhizomes, a single plant can acquire a large area. The current study was designed and carried out to appraise the heamolytic and thrombolytic potential of the plant’s extract. Result indicated that the methanolic extract of L. cornuta (at dose 20 μg/mL) possess minimum haemolytic activity (2 ± 0.001 %) whereas ethyl acetate extract (at dose 100 μg/mL) possess highest haemolytic activity (9 ± 0.35). Haemolytic percentage was found to be increasing with increase in dose. In this study, ethyl acetate extract was found to possess the maximum thrombolytic activity i.e. 64 ± 0.18 % at a concentration of 100 μg/mL and it is due to the presence of some phytochemical constituents.

Keywords

Launaea cornuta Heamolytic Thrombolytic
Khan, Z., Iqbal, M., Ahmed, W., Khayam, M., Kiran, S., Subhan, A., & Yasmine, R. (2016). in vitro Haemolytic and Thrombolytic Activities of Launaea cornuta. Asian Journal of Chemistry, 28(5), 1084–1086. https://doi.org/10.14233/ajchem.2016.19591
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