Institute of Biotechnology, Nanjing University of Science and Technology, Nanjing 210094, P.R. China; School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, P.R. China ;These authors contributed equally to this work.
Y.J. Jin
Institute of Biotechnology, Nanjing University of Science and Technology, Nanjing 210094, P.R. China ;These authors contributed equally to this work.
C.G. Zheng
Department of Coloprectology, The Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325035, P.R. China
Q.Q. Tang
School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, P.R. China
G. Liang
Institute of Biotechnology, Nanjing University of Science and Technology, Nanjing 210094, P.R. China ; School of Pharmacy, Wenzhou Medical College, Wenzhou 325035, P.R. China
S.L. Yang
Institute of Biotechnology, Nanjing University of Science and Technology, Nanjing 210094, P.R. China
Corresponding Author(s) : S.L. Yang
shulin_yang@126.com
Asian Journal of Chemistry,
Vol. 25 No. 12 (2013): Vol 25 Issue 12
The 1,3-dipolar cycloaddition of azomethine ylides derived from acenaphthenequinone and a-amino acid (sarcosine) to a series of 2,5-bis(fluorobenzylidene) cyclopentanones afforded novel spiro-cyclopentanone-pyrrolizines chemo-, regio- and stereoselectively in quantitative yields (95-96 %). The crystal structure of one compound containing bis(2,6- difluorobenzyl) (2b) is described. The cyclopentane rings in bis(2,6-difluorobenzyl) (2b) have an envelope conformation.
Keywords
Atom economicSpiro-cyclopentanone-pyrrolizines1,3-Dipolar cycloadditionX-ray crystallography
Full Article
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Zhao, C., Jin, Y., Zheng, C., Tang, Q., Liang, G., & Yang, S. (2013). A Highly Atom Economic, Chemo-, Regio- and Stereoselective Synthesis and Crystal Structure of Novel Spiro-Cyclopentanone. Asian Journal of Chemistry, 25(12), 6968–6970. https://doi.org/10.14233/ajchem.2013.15413
