An Improved Synthesis of Apigenin and Luteolin

A. Rambabu; K.J. Kumari; M. Baby Ramana; M.V. Ramani; G.V. Subbaraju; B. Hari Babu

doi:10.14233/ajchem.2016.19613

Issue

Vol. 28 No. 5 (2016): Vol 28 Issue 5

Issue Published : January 30, 2016

This work is licensed under a Creative Commons Attribution 4.0 International License.

An Improved Synthesis of Apigenin and Luteolin

https://doi.org/10.14233/ajchem.2016.19613

A. Rambabu

Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522 510, India

K.J. Kumari

Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522 510, India

M. Baby Ramana

Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522 510, India

M.V. Ramani

Natsol Laboratories Private Limited, Ramky Commercial Hub, J.N. Pharma City, Visakhapatnam-531 019, India

G.V. Subbaraju

Natsol Laboratories Private Limited, Ramky Commercial Hub, J.N. Pharma City, Visakhapatnam-531 019, India

B. Hari Babu

Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522 510, India

Corresponding Author(s) : B. Hari Babu

dr.b.haribabu@gmail.com

Asian Journal of Chemistry, Vol. 28 No. 5 (2016): Vol 28 Issue 5
Article Published : January 30, 2016

Abstract

Apigenin and luteolin are the antioxidant flavonoids found in foods such as parsley, artichoke, basil and celery. Both of these compounds have shown the ability to protect cells against cancer and also to inhibit DNA oxidative damage. These flavonoids are part of many nutraceutical formulations available in the market. There is a need for the development of cost effective methodologies to produce them in large quantities. The synthetic process developed for both these compounds is general and can be applied for other flavonoids also. An industrially applicable high pure product, cost effective synthesis and general synthetic method has been developed and presented.

Keywords

Optimized synthesis Apigenin Luteolin

Rambabu, A., Kumari, K., Ramana, M. B., Ramani, M., Subbaraju, G., & Babu, B. H. (2016). An Improved Synthesis of Apigenin and Luteolin. Asian Journal of Chemistry, 28(5), 1139–1143. https://doi.org/10.14233/ajchem.2016.19613

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References

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References

T. Hirano, K. Oka and M. Akiba, Res. Commun. Chem. Pathol. Pharmacol., 64, 69 (1989).

G.G.J.M. Kuiper, J.G. Lemmen, B. Carlsson, J.C. Corton, H. Safe, T. van der Saag, B. van der Burg and J.-A. Gustafsson, Endocrinology, 139, 4252 (1998); doi:10.1210/endo.139.10.6216.

I.-K. Wang, S.-Y. Lin-Shiau and J.-K. Lin, Eur. J. Cancer, 35, 1517 (1999); doi:10.1016/S0959-8049(99)00168-9.

J. Mann, Secondary Metabolism, Oxford University Press, U.K., edn 2, pp. 279-280 (1992).

A. Ulubelen, M. Miski, P. Neuman and T.J. Mabry, J. Nat. Prod., 42, 261 (1979); doi:10.1021/np50003a002.

K. Shimoi, H. Okada, M. Furugori, T. Goda, S. Takase, M. Suzuki, Y. Hara, H. Yamamoto and N. Kinae, FEBS Lett., 438, 220 (1998); doi:10.1016/S0014-5793(98)01304-0.

M. López-Lázaro, Mini Rev. Med. Chem., 9, 31 (2009); doi:10.2174/138955709787001712.

T. Takahashi, M. Kobori, H. Shinmoto and T. Tsushida, Biosci. Biotechnol. Biochem., 62, 2199 (1998); doi:10.1271/bbb.62.2199.

S. Kawaii, Y. Tomono, E. Katase, K. Ogawa and M. Yano, Anticancer Res., 19, 1261 (1999).

F. Yin, E. Giuliano and J. van Herle, Thyroid, 9, 369 (1999); doi:10.1089/thy.1999.9.369.

J. Wang, R.-G. Zhou, T. Wu, T. Yang, Q.-X. Qin, L. Li, B. Yang and J. Yang, J. Chem. Res., 36, 121 (2012); doi:10.3184/174751912X13285269293913.

W.A. Hutchins and T.S. Wheeler, J. Chem. Soc., 91 (1939); doi:10.1039/jr9390000091.

J. Kim, P. Kwang-Su, L. Chaewoon and C. Youhoon, Bull. Korean Chem. Soc., 28, 2527 (2007); doi:10.5012/bkcs.2007.28.12.2527.

J. Menezes, S. Manjrekar, V. Pai, E. Patre and G. Tilve, Indian J. Chem., 48B, 1311 (2009).

R. Robinson and K. Venkataraman, J. Chem. Soc., 129, 2344 (1926); doi:10.1039/jr9262902344.

C. Gulati, R. Seth and K. Venkataraman, Org. Synth. Coll., 2, 522 (1943); 15, 70 (1935).

K. Ahluwalia, P. Bhagat, R. Aggarwal and R. Chandra, Intermediates for Organic Synthesis, I.K International Pvt. Ltd., India (2005).

A. Rambabu, M. Krishnamurthy, B. Haribabu and G.V. Subbaraju, Optimized Synthesis of 4',5,7-trimethoxy Apigenin, International Conference on Pure and Applied Chemistry (ICPAC-2014), Mauritius, 23-27 June 2014.

K. Yamasaki, R. Hishiki, E. Kato and J. Kawabata, ACS Med. Chem. Lett., 2, 17 (2011); doi:10.1021/ml100171x.

Y.F. Tong, S. Chen, Y.H. Cheng and S. Wu, Chin. Chem. Lett., 18, 407 (2007); doi:10.1016/j.cclet.2007.01.049.

Issue

Vol. 28 No. 5 (2016): Vol 28 Issue 5

An Improved Synthesis of Apigenin and Luteolin

Corresponding Author(s) : B. Hari Babu

Abstract

Keywords

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