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Vol. 28 No. 5 (2016): Vol 28 Issue 5

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Synthesis and Characterization of Ethyl 7-Acetyl-2-substituted 3-(substituted benzoyl)indolizine-1-carboxylates for in vitro Anticancer Activity

https://doi.org/10.14233/ajchem.2016.19582
C. Sandeep
Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga-577 203, India; Institute for Stem Cell Biology and Regenerative Medicine, NCBS, TIFR, GKVK, Bellary Road, Bangalore-560 065, India
Basavaraj Padmashali
Department of Chemistry, Sahyadri Science College (Autonomous), Shimoga-577 203, India; Department of Studies and Research in Chemistry, School of Basic Sciences, Rani Channamma University, Belagavi-591 156, India
Katharigatta N. Venugopala
Department of Biotechnology and Food Technology, Durban University of Technology, Durban-4001, South Africa
Rashmi S. Kulkarni
Department of Chemistry, Jain University, Bangalore-560 019, India
Rashmi Venugopala
Department of Public Health Medicine, University of KwaZulu-Natal, Howard College Campus, Durban-4001, South Africa
Bharti Odhav
Department of Biotechnology and Food Technology, Durban University of Technology, Durban-4001, South Africa

Corresponding Author(s) : Basavaraj Padmashali

basavarajpadmashali@yahoo.com

Asian Journal of Chemistry, Vol. 28 No. 5 (2016): Vol 28 Issue 5

Abstract

Efficient synthesis of a series of novel indolizines (2a-r) has been achieved by reaction between 4-acetyl-1-[2-(substituted phenyl)-2-oxoethyl]pyridin-1-ium bromide and substituted alkynes in presence of anhydrous potassium carbonate in dimethyl formamide medium. The title compounds have been characterized by spectroscopic techniques and elemental analysis. Selected compounds 2b, 2h, 2i, 2q and 2r have been screened for in vitro anticancer activity using adriamycin as positive control and it was found that compounds 2b, 2q and 2r have shown significant anticancer activity.

Keywords

Anticancer Characterization Indolizine analogues Synthesis
Sandeep, C., Padmashali, B., Venugopala, K. N., Kulkarni, R. S., Venugopala, R., & Odhav, B. (2016). Synthesis and Characterization of Ethyl 7-Acetyl-2-substituted 3-(substituted benzoyl)indolizine-1-carboxylates for in vitro Anticancer Activity. Asian Journal of Chemistry, 28(5), 1043–1048. https://doi.org/10.14233/ajchem.2016.19582
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