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Vol. 31 No. 1 (2019): Vol 31 Issue 1

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Synthesis and Antimicrobial Evaluation of New Pyrrolo-isoxazolidine Derivatives

https://doi.org/10.14233/ajchem.2019.21726
Mohamad Yusuf
Department of Chemistry, Punjabi University, Patiala-147002, India
Baldev Singh
Department of Chemistry, Punjabi University, Patiala-147002, India

Corresponding Author(s) : Mohamad Yusuf

yusuf_sah04@yahoo.co.in

Asian Journal of Chemistry, Vol. 31 No. 1 (2019): Vol 31 Issue 1

Abstract

In the present study, pyrrolo-isoxazolidines 3(a-l) and 4(a-e), 4g, 4i, 4j have been synthesized by using the 1,3-dipolar cycloaddition reactions of nitrones 1(a-l) with ester substituted N-aryl maleimide (2b). These heterocycles have been obtained in cis and trans diastereomeric forms. The structures of newly synthesized heterocycles have been confirmed from their spectroscopic parameters such as IR, 1H NMR, 13C NMR and ESI-MS. The in vitro antimicrobial evaluation of these compounds were also investigated. Most of the prepared heterocycles showed significant antimicrobial properties. C3-phenyl substituted products exhibited the remarkable antibacterial behaviours while C3-thienyl/furyl substituted heterocycles proved themselves potent antifungal agents.

Keywords

Nitrones N-Aryl-maleimide Cycloaddition Pyrrolo-isoxazolidines Antimicrobial activities
Yusuf, M., & Singh, B. (2018). Synthesis and Antimicrobial Evaluation of New Pyrrolo-isoxazolidine Derivatives. Asian Journal of Chemistry, 31(1), 220–228. https://doi.org/10.14233/ajchem.2019.21726
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