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Vol. 25 No. 11 (2013): Vol 25 Issue 11

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Determination of Cefoperazone Sodium in Pharmaceutical Formulations by Fe3+-Phenanthroline Spectrophotometry

https://doi.org/10.14233/ajchem.2013.14204
Ou Sha
School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, P.R. China ; Analysis and Test Center of Jiangsu Marine Resources Development Research Institute, Lianyungang 222001, P.R. China
Yin Liao
School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, P.R. China
Yun Zhou
School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, P.R. China
Si Liang Zhang
School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, P.R. China
Weixing Ma
School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, P.R. China

Corresponding Author(s) : Ou Sha

7993259@163.com

Asian Journal of Chemistry, Vol. 25 No. 11 (2013): Vol 25 Issue 11

Abstract

A new method for determination cefoperazone by spectrophotometry was developed based on Fe3+ as the oxidizer of cefoperazone and phenanthroline as the colouring reagent of Fe2+, which was produced from Fe3+. Under the optimum conditions, the relationship between the absorbance and the concentration of cefoperazone was linear in the range of 0.50-12.50 mg/L, the regression equation was A = 0.1179 c (c: mg/L) +0.0003, the relative coefficient was 0.9985. The proposed methods have been applied to the determination of cefoperazone content in pharmaceutical formulations with satisfactory results.

Keywords

Spectrophotometry Cefoperazone Phenanthroline
Sha, O., Liao, Y., Zhou, Y., Liang Zhang, S., & Ma, W. (2013). Determination of Cefoperazone Sodium in Pharmaceutical Formulations by Fe3+-Phenanthroline Spectrophotometry. Asian Journal of Chemistry, 25(11), 5965–5967. https://doi.org/10.14233/ajchem.2013.14204
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