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Vol. 25 No. 11 (2013): Vol 25 Issue 11

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Free Radical Scavenging Activities of the Extracts from Taxus chinensis var. mairei

https://doi.org/10.14233/ajchem.2013.14322
Ye Zhang
Department of Chemistry, Guilin Normal College, Guangxi 541001, P.R. China
Yilin Fang
Department of Chemistry, Guilin Normal College, Guangxi 541001, P.R. China
Zhongquan Cheng
Department of Chemistry, Guilin Normal College, Guangxi 541001, P.R. China
Xianxian Liu
Department of Chemistry, Guilin Normal College, Guangxi 541001, P.R. China
Xianghui Yi
Department of Chemistry, Guilin Normal College, Guangxi 541001, P.R. China ; Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guilin 541006, P.R. China

Corresponding Author(s) : Xianghui Yi

yixianghui2008@yahoo.com.cn

Asian Journal of Chemistry, Vol. 25 No. 11 (2013): Vol 25 Issue 11

Abstract

Under ultrasound, Taxus chinensis var. mairei were extracted with ethanol at 80 ºC to offer ethanol extract. Ethanol extract was further extracted with chloroform and separated by column chromatography to offer paclitaxel. Their free radical scavenging activity were evaluated and compared with the common antioxidant butylated hydroxytoluene, employing DPPH• assay, ABTS+• assay, O2•− assay and OH• assay. The results showed that ethanol extract exhibited better scavenging activity than the common antioxidant butylated hydroxytoluene in these four assays, with IC50 of 13.19, 2.65, 25.33 and 343.00 μg/mL, while paclitaxel showed less scavenging activity than butylated hydroxytoluene, with IC50 of 1.49, 46.14, 3.52 and 2.17 mg/mL, respectively. The antioxidant activity screening results demonstrated that ethanol extract displayed better antioxidant activity than that of paclitaxel and the excellent antioxidant activity of ethanol extract may be attributed to other compositions of ethanol extract.

Keywords

Paclitaxel Free radical scavenging activity Ultrasound-assisted extract Taxus chinensis var mairei
Zhang, Y., Fang, Y., Cheng, Z., Liu, X., & Yi, X. (2013). Free Radical Scavenging Activities of the Extracts from Taxus chinensis var. mairei. Asian Journal of Chemistry, 25(11), 6213–6215. https://doi.org/10.14233/ajchem.2013.14322
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