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Vol. 25 No. 11 (2013): Vol 25 Issue 11

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A New Chromone from the Flower Buds of Magnolia fargesii and its Anti HIV-1 Activity

https://doi.org/10.14233/ajchem.2013.14219
Gang Du
School of life Sciences, Yunnan University, Kunming 650091, P.R. China ; Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Liying Yang
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Yanqiong Shen
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Lidang Shu
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Meng-Liang Wen
School of life Sciences, Yunnan University, Kunming 650091, P.R. China
Qiu-Fen Hu
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Asian Journal of Chemistry, Vol. 25 No. 11 (2013): Vol 25 Issue 11

Abstract

A new chromone, fargesiichromone A (1) was isolated from the flower buds of Magnolia fargesii. The structure of newly isolated fargesiichromone (1) was elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compound 1 was also evaluated for the anti HIV-1 activity and it showed anti HIV-1 activity with EC50 4.18 μg/mL, CC50 > 200 μg/mL and therapeutic index value above 47.8.

Keywords

Magnolia fargesii Chromone Anti HIV-1 activity
Du, G., Yang, L., Shen, Y., Shu, L., Wen, M.-L., & Hu, Q.-F. (2013). A New Chromone from the Flower Buds of Magnolia fargesii and its Anti HIV-1 Activity. Asian Journal of Chemistry, 25(11), 6455–6456. https://doi.org/10.14233/ajchem.2013.14219
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References
  1. M. Miyazawa, H. Kasahara and H. Kameoka, Phytochemistry, 31, 3666 (1992).
  2. Y.J. Lee, Y.M. Lee, C.K. Lee, J.K. Jung, S.B. Han and J.T. Hong, Pharm. Therap., 130, 157 (2011).
  3. Y.L. Huang, C.C. Chen, Y.P. Chen, H.Y. Hsu and Y.H. Kuo, Planta Med., 56, 237 (1990).
  4. M. Miyazawa, Y. Ishikawa, H. Kasahara, J. Yamanaka and H. Kameoka, Phytochemistry, 35, 611 (1994).
  5. J. Lee, D. Lee, D.S. Jang, J.W. Nam, J.P. Kim, K.H. Park, M.S. Yang and E.K. Seo, Chem. Pharm. Bull., 55, 137 (2007).
  6. J. Lee, E.K. Seo, D.S. Jang, T.J. Ha, J.P. Kim, J.W. Nam, G. Bae and J.S. Kim, Chem. Pharm. Bull., 57, 298 (2009).
  7. M.A. Kelm and M.G. Nair, Stud. Nat. Prod. Chem., 24, 845 (2000).
  8. K.Y. Jung, D.S. Kim, S.H. Park, I.S. Lee, S.R. Oh, J.J. Lee, E.H. Kim and H.K. Lee, Phytochemistry, 48, 1383 (1998).
  9. J.Y. Fang, T.H. Tsai, C.F. Hung and W.W. Wong, J. Pharm. Pharmacol., 56, 1493 (2004).
  10. S. Oshimi, Y. Tomizawa, Y. Hirasawa, T. Honda, A. Widyawaruyanti, W. Ekasari, M. Rudyanto and H. Morita, Bioorg. Med. Chem. Lett., 18, 3761 (2008).
  11. K.M. Biswas and H. Mallik, Phytochemistry, 25, 1727 (1986).
  12. L.Y. Ma, S.C. Ma, F. Wei, R.C. Lin, P.P. But, S.H. Lee and S. F. Li Chem. Pharm. Bull., 51, 1264 (2003).
  13. J. Ungwitayatorn, C. Wiwat, W. Samee, P. Nunthanavanit and N. Phosrithong, J. Mol. Struct., 1001, 152 (2011).
  14. Y.Y. Sun, G.M. Liu, H. Huang and P.Z. Yu, Phytochemistry, 75, 169 (2012).
  15. P.L. Darke and J.R. Huff, Adv. Pharmacol., 25, 399 (1994).
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