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Vol. 25 No. 10 (2013): Vol 25 Issue 10

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Synthesis of Benzothiophenones and Naphthothiophenone as Anticholinesterases

https://doi.org/10.14233/ajchem.2013.14168
D.I. Jung
Department of Chemistry, Dong-A University, Busan 604-714, South Korea

Corresponding Author(s) : D.I. Jung

dijung@dau.ac.kr

Asian Journal of Chemistry, Vol. 25 No. 10 (2013): Vol 25 Issue 10

Abstract

Since AChE and BuChE belong to the same serine hydrolazes, we designed and synthesized compounds 1-6 as anticholinesterases and measured their inhibition poteucies on ChEs. 7-Methoxy-3H-benzo[c]thiophen-1-one 4, 4,6-dibromo-5,7-methoxy-3H-benzo[c]thiophe-1-one 5 and 9-methoxy-3H-naphtho-[2,3-c]thiophen-1-one 6 were synthesized by using ethyl 2-methoxy-6-methylbenzoate, ethyl 3,4-dibromo-2,4-dimethoxy-6-methylbenzoate and ethyl 1-methoxy-3-methyl-2-naphthoate.

Keywords

Cholinesterase Inhibition Benzothiophenone Naphthothiophenone
Jung, D. (2013). Synthesis of Benzothiophenones and Naphthothiophenone as Anticholinesterases. Asian Journal of Chemistry, 25(10), 5325–5327. https://doi.org/10.14233/ajchem.2013.14168
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