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This work is licensed under a Creative Commons Attribution 4.0 International License.
Controlled Release of (SBA-15)-Carvedilol Drug
Corresponding Author(s) : Qing-Zhou Zhai
Asian Journal of Chemistry,
Vol. 25 No. 10 (2013): Vol 25 Issue 10
Abstract
In this paper, the SBA-15 molecular sieve was prepared by hydrothermal method. Carvedilol was loaded in the SBA-15 with impregnation method and the loading capacity of carvedilol is 443.50 mg/g. By means of chemical analysis, powder X-ray diffraction and low-temperature nitrogen adsorption-desorption technique at 77 K, the products were characterized. The results showed that carvedilol guest molecules had been successfully encapsulated into the channels of SBA-15. A research of the slow release effect of carvedilol encapsulated in SBA-15 mesoporous material was studied in simulated body fluid. The drug cumulative release is 19.6 % in 1 h and release 99.3 % after 32 h and tended to tranquilization. The drug release has tended to tranquilization to 19.2% after 4 h in simulated gastric fluid and to 63.2 % after 8 h in simulated intestinal fluid.
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References
Y. Han and D. Zhang, Curr. Opin. Chem. Eng., 1, 129 (2012).
C.T. Kresge, M.E. Leonowicz, W.J. Roth, J.C. Vartuli and J.S. Beck, Nature, 359, 710 (1992).
J.S. Beck, J.C. Vartuli, W.J. Roth, M.E. Leonowicz, C.T. Kresge, K.D. Schmitt and T.W. Chu, J. Am. Chem. Soc., 114, 10834 (1992).
D.Y. Zhao, Q.S. Huo, J.L. Feng, B.F. Chmelka and G.D. Stucky, J. Am. Chem. Soc., 120, 6024 (1998).
D.Y. Zhao, J.L. Feng, Q.S. Huo, N. Melosh, G.H. Fredrickson, B.F. Chmelka and G.D. Stucky, Science, 279, 548 (1998).
S. Ajitha and S. Sugunan, J. Porous Mater., 17, 341 (2010).
J. Ma, J. Chu, L.S. Qiang and J.Q. Xue, Bull. Chin. Ceram. Soc., 31, 301 (2012).
J.Q. Jiang and S.M. Ashekuzzaman, Curr. Opin. Chem. Eng., 1, 191 (2012).
A. Corma, Chem. Rev., 97, 2373 (1997).
E.D. Davis, Nature, 417, 813 (2002).
M. Vallet-Regi, A. Ramila, R. del Real and P. Perez-Pariente, Chem. Mater., 13, 308 (2001).
M. Vallet-Regi, J.C. Doadrio and A.L. Doadrio, Solid State Ionics, 172, 435 (2004).
V.P. Lehto, K.V. Heikkila and J.J. Paski, Therm. Anal. Calorimet., 80, 393 (2005).
P. Horcajada,A. Ramila, J. Perez-Pariente and M. Vallet-Regi, Micropor. Mesopor. Mater., 68, 105 (2004).
T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi and T. Yamamuro, J. Biomed. Mater. Res., 24, 721 (1990).
Z.H. Luan, M. Hartmann, D.Y. Zhao and L. Kevan, Chem. Mater., 11, 1621 (1999).
T.V. Sreevidya and B. Narayana, Indian J. Chem. Technol., 16, 74 (2009).
S. Brunauer, P.H. Emmett and E. Teller, J. Am.Chem. Soc., 60, 309 (1938).
E. Barrett, L.G. Joyner and P.P. Halenda, J. Am. Chem. Soc., 73, 373 (1951).
J.C. Doadrio, E.M.B. Sousa, B. Izquierdo-Barba,A.L. Doadrio, J. PerezPariente and M. Vallet-Regi, J. Mater. Chem., 16, 462 (2006).
M. Vallet-Regi, J.C. Doadrio, A. Doadrio, L. Izquierdo-Barba and J. Perez-Pariente, Solid State Ionics, 172, 435 (2004).
A.L. Doadrio, E.M.B. Sousa, J.C. Doadrio, J. Perez-Pariente, I. IzquierdoBarba and M. Vallet-Regi, J. Control. Rel., 97, 125 (2004).
T. Higuchi, J. Pharm. Sci., 52, 1145 (1963).
L.B. Yang and A.R. Fassihix, J. Pharm. Sci., 85, 170 (1996).
H.J. Kim, J.E. Ahn, S.J. Haam, Y.G. Shul, S.Y. Song and T.S. Tatsumi, J. Mater. Chem., 16, 1617 (2006).
A.R. Fassihi and W.A. Ritschel, J. Pharm. Sci., 82, 750 (1993).
S.M. Song, Z.L. Wang and W.B. Li, Physical Chemistry, Beijing: Higher Education Publishing House, p. 219 (1993)