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Synthesis and Bioassay of Novel Phenylhydrazine and 2,4-Dinitrophenylhydrazine Substituted Carbazoles
Corresponding Author(s) : Zubi Sadiq
Asian Journal of Chemistry,
Vol. 25 No. 10 (2013): Vol 25 Issue 10
Abstract
The efficient and rapid synthesis of phenylhydrazine and 2,4-dinitrophenylhydrazine substituted carbazole derivatives is reported using both strategies; conventional and microwave. Both newly prepared compounds shares the same acidic media. Microwave irradiations demonstrated much suitable results with respect to every aspect. Antibacterial and antifungal potential of both compounds were evaluated in terms of minimum inhibitory concentration against Escherichia coli, Staphylococcus aureus, Pasteurella multocida, Bacillus subtilis, Aspergillus flavus, Aspergillus niger, Alternaria solani and Rhizoctonia solani.
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References
(a) N. Haider, J. Heterocycl. Chem., 39, 511 (2002); (b) G. Yaqub, A. Hannan, E. Akbar, M. Usman, A. Hamid, Z. Sadiq and M. Iqbal, J. Chem., Article ID 818739 (2013).
A.D. Isravel and J.R.P. Karnam, Acta Pharm., 53, 287 (2003).
K. Hirata, C. Ito, H. Furukawa, M. Itoigawa, L.M. Cosentino and K.-H. Lee, Bioorg. Med. Chem. Lett., 9, 119 (1999).
G. Yaqub, E.A. Hussain, M.A. Rehman and B. Mateen, Asian J. Chem., 21, 2485 (2009).
W.J. Lao, Y.H. Zhang, Y.Q. Liu, Q.J. Wu, Z.X. Huang and Q.Y. Ou, Chin. Chem. Lett., 12, 321 (2001)