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Ligand-free CuSO4-Catalyzed C-N Coupling Reaction of Aryl Halides with Alkylamines or N-heterocycles in Aqueous Solution System
Corresponding Author(s) : Jingyu Si
Asian Journal of Chemistry,
Vol. 25 No. 10 (2013): Vol 25 Issue 10
Abstract
C-N coupling can be achieved successfully under 80 ºC in aqueous nBu4NOH using CuSO4 as a catalyst. The study of substrate applicability demonstrated that the C-N coupling reaction of aryl iodides and bromides with alkylamines or N-heterocycles could be completed smoothly in this catalytic system.
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References
A. de Meijere and F. Diederich, Metal-Catalyzed Cross-Coupling Reactions, Wiley-VCH Verlag GmbH and Co. KGaA, edn. 2, p. 26 (2004).
D.-W. Ma, Y.-D. Zhang, J.-C. Yao, S.-H. Wu and F.-G. Tao, J. Am. Chem. Soc., 120, 12459 (1998).
Y. Dai, H.-S. Liu, X.-J. Feng and M. Bao, Chin. J. Catal., 32, 1617 (2001).
J.-Y. Li, Y.-J. Wu, Z.-X. Han and S. Jiang, Chem. J. Chinese Univ., 29, 1555 (2008).
C.-T. Yang, Y. Fu, Y.-B. Huang, J. Yi, Q.X. Guo and L. Liu, Angew. Chem., Int. Ed., 48, 7398 (2009).