Issue

Vol. 28 No. 4 (2016): Vol 28 Issue 4

Copyright (c) 2016 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthetic Approach for Novel Fluorine Substituted Thiadiazaphosphole Fused 1,2,4-Triazinopyridiazine Moieties as Bactericidal Agents

https://doi.org/10.14233/ajchem.2016.19555
Mohammed Saleh Tawfek Makki
Chemistry Department, Faculty of Science, King Abdul Aziz University, Jeddah 80203, Kingdom of Saudi Arabia
Reda Mohammady Abdel Rahman
Chemistry Department, Faculty of Science, King Abdul Aziz University, Jeddah 80203, Kingdom of Saudi Arabia
Ola Ahmad Abu Ali
Chemistry Department, Faculty of Science, King Abdul Aziz University, Jeddah 80203, Kingdom of Saudi Arabia

Corresponding Author(s) : Ola Ahmad Abu Ali

lolo_aa4@hotmail.com

Asian Journal of Chemistry, Vol. 28 No. 4 (2016): Vol 28 Issue 4

Abstract

Novel fluorine substituted thiadiazaphosphole fused 1,2,4-triazino pyridiazines (7 and 8) were synthesized by refluxing of 4-amino-6-styryl-3-mercapto-1,2,4-triazin-5-one (2) with triethylphosphite and/or triethylphospate in dry ethyl benzene followed by cycloaddition with hydrazine in warm ethanol-piperidine and finally boil with trifluoroacetic anhydride in dioxane. Structure of the products was elucidated with the help of elemental analysis and spectral data. All the target compounds evaluated as bactericidal agents against Escherichia coli compared with chloromycetin as standard antibiotic.

Keywords

Synthetic Thiadiazaphospholo-1,2,4-triazine Bactericidal
Tawfek Makki, M. S., Abdel Rahman, R. M., & Abu Ali, O. A. (2015). Synthetic Approach for Novel Fluorine Substituted Thiadiazaphosphole Fused 1,2,4-Triazinopyridiazine Moieties as Bactericidal Agents. Asian Journal of Chemistry, 28(4), 917–920. https://doi.org/10.14233/ajchem.2016.19555
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. R.M. Abdel-Rahman, M.S.T. Makki and A.N. Al-Romaizan, Int. J. Org. Chem., 4, 247 (2014); doi:10.4236/ijoc.2014.44028.
  2. A.N. Al-Romaizan, M.S.T. Makki and R.M. Abdel-Rahman, Int. J. Org. Chem., 4, 154 (2014); doi:10.4236/ijoc.2014.42017.
  3. T.E. Ali, R.M. Abdel-Rahman, F.I. Hanafy and S.M. El-Edfawy, Phosphorus Sulfur Silicon Rel. Elem., 183, 2565 (2008); doi:10.1080/10426500801967864.
  4. R.M. Abdel-Rahman, Trends in Heterocycl. Chem., 8, 187 (2002).
  5. R.M. Abdel-Rahman, M.A. Ibrahim and T.E. Ali, Eur. J. Chem., 1, 383 (2010); doi:10.5155/eurjchem.1.4.388-396.154.
  6. Z. El-Gendy, J.M. Morsy, H.A. Allimony, W.R. Abdel-Monem and R.M. Abdel-Rahman, Pharmazie, 56, 376 (2001).
  7. Z. El-Gendy, J.M. Morsy, H.A. Allimony, W.R. Abdel-Monem and R.M. Abdel-Rahman, Phosphorus Sulfur Silicon Rel. Elem., 178, 2055 (2003); doi:10.1080/10426500390228738.
  8. A.S. Al-Harbi, R.M. Abdel-Rahman and A.M. Asiri, Eur. J. Chem., 6, 63 (2015); doi:10.5155/eurjchem.6.1.63-70.1147.
  9. A.S. Al-Harbi, R.M. Abdel-Rahman and A.M. Asiri, Int. J. Org. Chem., 4, 142 (2014).
  10. M.S.T. Makki, R.M. Abdel-Rahman and K.A. Khan, J. Chem., Article ID 430573 (2014). http://dx.doi.org110.115/2014/430573.
  11. T.E. Ali and R.M. Abdel-Rahman, J. Sulfur Chem., 35, 339 (2014); doi:10.1080/17415993.2014.896363.
  12. R.M. Abdel-Rahman and T.E. Ali, Monatsh. Chem., 144, 1243 (2013); doi:10.1007/s00706-013-0934-6.
  13. H.A. Zaher, R. Mohammady and Y.A. Ibrahim, J. Heterocycl. Chem., 21, 905 (1984); doi:10.1002/jhet.5570210355.
  14. T.E. Ali and S.S. Halacheva, Heteroatom Chem., 20, 117 (2009); doi:10.1002/hc.20520.
  15. T.E. Ali, Phosphorus Sulfur Silicon Rel. Elem., 185, 88 (2009); doi:10.1080/10426500802713309.
  16. C.D. Reddy, G.T. Reddy and M.S. Reddy, Asian J. Chem., 5, 291 (1993).
  17. I.B. Paek, S.Y. Kim, M.S. Kim, J. Kim, G. Lee and H.S. Lee, J. Toxicol. Environ. Health, 70, 1356 (2007); doi:10.1080/15287390701434307.
  18. J.Y. Winum, M. Rami, A. Scozzafava, J.L. Montero and C. Supuran, Med. Res. Rev., 28, 445 (2008); doi:10.1002/med.20112.
  19. R.M. Abdel-Rahman, M.S.T. Makki, T.E. Ali and M.A. Ibrahim, Curr. Org. Synth., 10, 136 (2013); doi:10.2174/1570179411310010006#sthash.bRXt3huG.dpuf.
  20. R.M. Abdel-Rahman, Pharmazie, 56, 18 (2001).
  21. C.H. Collins, Microbiological Methods, Butterworths, London, p. 364 (1967).
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 0 Download : 1