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Vol. 25 No. 8 (2013): Vol 25 Issue 8

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Design, Synthesis and Characterization of Novel Biodegradable Poly(urethane-urea) for Biomedical Applications

https://doi.org/10.14233/ajchem.2013.13961
N. Hu
College of Bioengineering, Chongqing University, Chongqing 400030, P.R. China
C.S. Ruan
Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China
X.Q. Ning
College of Bioengineering, Chongqing University, Chongqing 400030, P.R. China
C.M. Xu
College of Bioengineering, Chongqing University, Chongqing 400030, P.R. China

Corresponding Author(s) : C.S. Ruan

henry-cs@hotmail.com

Asian Journal of Chemistry, Vol. 25 No. 8 (2013): Vol 25 Issue 8

Abstract

A series of novel biodegradable poly(urethane-urea) were designed and synthesized based on poly(D,L-lactic acid)diol, 1,6-hexamethylene diisocyanate and piperazine. Their structure and mechanical properties were characterized by fourier transform infrared spectroscopy, nuclear magnetic resonance and dynamic mechanical analysis. These results revealed that the successful introduction of the piperazine into the backbone of the biodegradable poly(urethane-urea) could make them have excellent mechanical properties. Increasing the hard segments of biodegradable poly(urethane-urea), the Tg and storage modulus of biodegradable poly(urethane-urea) increased from 29.35 to 55.63 ºC and from 2523 to 3295 MPa, respectively. Moreover, in vitro degradation tests confirmed that piperazine as the chain extender would improve the biodegradable stability of biodegradable poly(urethane-urea) and regulate its degradation rate.

Keywords

Poly(urethane-urea) Piperazine Mechanical property In Vitro degradation Poly(D,L-lactic acid)diol
Hu, N., Ruan, C., Ning, X., & Xu, C. (2013). Design, Synthesis and Characterization of Novel Biodegradable Poly(urethane-urea) for Biomedical Applications. Asian Journal of Chemistry, 25(8), 4327–4330. https://doi.org/10.14233/ajchem.2013.13961
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