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Vol. 25 No. 8 (2013): Vol 25 Issue 8

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Antileukemic Properties of Spermacoce Species

https://doi.org/10.14233/ajchem.2013.14218A
M.A. Sukari
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
R. Utami
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
B.K. Neoh
Sime Darby Technology Centre Sdn Bhd, Block A and B, UPM-MTDC Technology Centre III, Universiti Putra Malaysia, 43400 Selangor, Malaysia
G.C.L. Ee
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
S. Jusoh
Department of Animal Science, Faculty of Agriculture, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
S.M.M. Nor
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
M. Rahmani
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

Corresponding Author(s) : M.A. Sukari

aspollah@science.upm.edu.my

Asian Journal of Chemistry, Vol. 25 No. 8 (2013): Vol 25 Issue 8

Abstract

Antileukemic activity of th extracts and isolated compound from Spermacoce articularis, Spermacoce exilis and Spermacoce latifolia were carried out. All extracts of Spermacoce articularis as well as dichloromethane and ethyl acetate extracts of Spermacoce exilis showed strong activity against HL-60 cancer cell with IC50 value ranging from 0.4 to 7.2 μg/mL, whereas hexane extract of Spermacoce latifolia gave moderate activity with IC50 value of 13 ± 0.19 μg/mL. Ursolic acid as the major isolated constituent of these plants was found to have strong activity with IC50 of 1.3 ± 0.03 μg/mL against the same cancer cell.

Keywords

Spermacoce articularis Spermacoce exilis Spermacoce latifolia Ursolic acid Antileukemic
Sukari, M., Utami, R., Neoh, B., Ee, G., Jusoh, S., Nor, S., & Rahmani, M. (2013). Antileukemic Properties of Spermacoce Species. Asian Journal of Chemistry, 25(8), 4595–4598. https://doi.org/10.14233/ajchem.2013.14218A
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