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Vol. 25 No. 8 (2013): Vol 25 Issue 8

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Preparation of Ginkgolide B Polybutylcyanoacrylate Nanoparticles Suspension Powder-Injection

https://doi.org/10.14233/ajchem.2013.14547
Xi-Qing Yan
College of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China
Qing-Feng Jiang
College of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China ; Nuokai Biological Pharmaceutical Co. Ltd., Changsha 410008, Hunan Province, P.R. China
Jie-Li Lv
College of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China
Fang Ai
Department of Pediatric Surgery, First affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, P.R. China
Ze-Xin Li
Department of General Surgery, First affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, P.R. China
Pei-Yong Qiu
College of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China
Jun Yang
College of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan Province, P.R. China
Zhi-Liang Chen
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China

Corresponding Author(s) : Xi-Qing Yan

yxqtgxx@163.com; yxqdoctor@163.com

Asian Journal of Chemistry, Vol. 25 No. 8 (2013): Vol 25 Issue 8

Abstract

Ginkgolide B polybutylcyanoacrylate nanoparticles suspension suspension were prepared using polybutylcyanoacrylate as drug carrier by interface polycondensation method and the trehalose was selected as cryoproctant in forming the powder injection. The result showed that the encapsulation efficiency and the drug loading of the drug nanoparticles suspension were 96.74 ± 1.25 % and 5.74 ± 0.46 % respectively and the powder injection of the ginkgolide B polybutylcyanoacrylate nanoparticles suspension exhibited good appearance, re-dispersion and high stability at the room temperature. The high loading of ginkgolide B polybutylcyanoacrylate in nanoparticles suspension might successfully solve the insolubility of ginkgolide B in aqua solution and be possible used as a brain targeted candidate drug form.

Keywords

Ginkgolide B Nanoparticles Polybutylcyanoacrylate
Yan, X.-Q., Jiang, Q.-F., Lv, J.-L., Ai, F., Li, Z.-X., Qiu, P.-Y., … Chen, Z.-L. (2013). Preparation of Ginkgolide B Polybutylcyanoacrylate Nanoparticles Suspension Powder-Injection. Asian Journal of Chemistry, 25(8), 4670–4674. https://doi.org/10.14233/ajchem.2013.14547
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