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Vol. 25 No. 8 (2013): Vol 25 Issue 8

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Synthesis of Water Soluble C-10-Phenoxy Artemisinin-Chitosan Conjugate

https://doi.org/10.14233/ajchem.2013.14449
Dan Xiao
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P.R. China
Bo Yang
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P.R. China
Yun-Jian Chen
Kunming Pharmaceutical Group Corporation, Kunming 650100, P.R. China
Xia-Li Liao
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P.R. China
Xue-Min Yang
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P.R. China
Qi-Xue Qin
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P.R. China
Dong Yi
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P.R. China

Corresponding Author(s) : Bo Yang

yangbo6910@sina.com

Asian Journal of Chemistry, Vol. 25 No. 8 (2013): Vol 25 Issue 8

Abstract

A sort of C-10-phenoxy artemisinin-chitosan conjugate, in which C-10-phenoxy artemisinin was covalently bound to chitosan, was prepared and its aqueous solubility was evaluated. The results indicated that the conjugate (1.013 mg/mL) had much higher aqueous solubility than artemisinin (0.0084 mg/mL) and C-10-phenoxy artemisinin (0.0245 mg/mL). The conjugate will be potentially useful for their application as the prodrug of artemisinin.

Keywords

C-10-Phenoxy artemisinin Chitosan Conjugate Aqueous solubility
Xiao, D., Yang, B., Chen, Y.-J., Liao, X.-L., Yang, X.-M., Qin, Q.-X., & Yi, D. (2013). Synthesis of Water Soluble C-10-Phenoxy Artemisinin-Chitosan Conjugate. Asian Journal of Chemistry, 25(8), 4654–4656. https://doi.org/10.14233/ajchem.2013.14449
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References
  1. G. Marshall, Science, 290, 428 (2000).
  2. D.L. Klayman, Science, 228, 1049 (1985).
  3. X.D. Luo and C.C. Shen, Med. Res. Rev., 7, 29 (1987).
  4. R.K. Haynes, Eur. J. Org. Chem., 113 (2002).
  5. A.J. Lin, D.L. Klayman and W.K. Milhous, J. Med. Chem., 30, 2147 (1987).
  6. K.T. Batty, K.F.T. Ilett, T. Davis and M.E. Davis, J. Pharm. Pharmacol., 48, 22 (1996).
  7. P.H. van Vianen, D.L. Klayman, A.J. Lin, C.B. Lugt, A.L. van Engen, H.J. Kaay and B. Mons, Exp. Parasitol., 70, 115(1990).
  8. N. Bhattarai, J. Gunn and M.Q. Zhang, Adv. Drug. Deliv. Rev., 62, 83 (2010).
  9. A.C. Beekman, A.R.W. Barentsen and H.V. Wikström, J. Nat. Prod., 60, 325 (1997).
  10. N. Bhattarai, J. Gunn and M.Q. Zhang, Adv. Drug. Deliv. Rev., 62, 83 (2010).
  11. Y.B. Schuetz, R. Gurny and O. Jordan, Eur. J. Pharm. Biopharm., 68, 19 (2008).
  12. J. Wu and M. Sailor, Adv. Funct. Mater., 19, 73 (2009).
  13. B. Yang, J. Lin, Y. Chen and Y. Liu, Bioorg. Med. Chem., 17, 6311 (2009).
  14. A. Brossi, B. Venugopalan, G.L. Dominguez, H.J. Yeh, J.L. FlippenAnderson, P. Buchs, X.D. Luo, W. Milhous and W. Peters, J. Med. Chem., 31, 645 (1988).
  15. B.J. Kim and T. Sasaki, J. Org. Chem., 69, 3242 (2004).
  16. H. Lai, Life Sci., 76, 1267 (2005).
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