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Vol. 25 No. 8 (2013): Vol 25 Issue 8

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Kinetic Spectrophotometric Methods for the Determination of Isatin

https://doi.org/10.14233/ajchem.2013.14067
Zeid A. Alothman
Advanced Materials Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
Masoom Raza Siddiqui
Advanced Materials Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
Saikh Mohammad Wabaidur
Advanced Materials Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
Hamad A. Al-Lohedan
Surfactant Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
Mohd. Sajid Ali
Surfactant Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
M.Z.A. Rafiquee
Surfactant Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia

Corresponding Author(s) : Masoom Raza Siddiqui

siddiqui124@gmail.com

Asian Journal of Chemistry, Vol. 25 No. 8 (2013): Vol 25 Issue 8

Abstract

Simple, rapid and sensitive kinetic spectrophotometric methods are described for the analysis of isatin in pure form and in mixture. The procedures were based on the kinetic investigations and studies were done upon the oxidation of isatin with potassium permanganate in basic medium. Various parameters affecting the colour developments were investigated and parameters were optimized. The reliability and the analytical performance of the proposed methods were validated for its linearity, range, accuracy and precision. The calibration curves were linear over the range of 5-50 μg mL-1. The limit of detection and limit of quantitation of the two methods ranges from 3.4 × 10-4-0.878 and 1.05 × 10-3-2.663, respectively. The possible mechanism of the reaction is also proposed.

Keywords

Isatin Spectrophotometry Method development Method validation
A. Alothman, Z., Raza Siddiqui, M., Mohammad Wabaidur, S., A. Al-Lohedan, H., Sajid Ali, M., & Rafiquee, M. (2013). Kinetic Spectrophotometric Methods for the Determination of Isatin. Asian Journal of Chemistry, 25(8), 4563–4568. https://doi.org/10.14233/ajchem.2013.14067
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