In vitro Radioprotective Activity of the Bryozoan Hyalinella punctata

Boris Pejin; Bojana Stanimirovic; Neda Djordjevic; Aleksandar Hegedis; Ivo Karaman; Mladen Horvatovic; Ksenija Radotic

doi:10.14233/ajchem.2013.14917

Issue

Vol. 25 No. 8 (2013): Vol 25 Issue 8

Issue Published : March 7, 2013

This work is licensed under a Creative Commons Attribution 4.0 International License.

In vitro Radioprotective Activity of the Bryozoan Hyalinella punctata

https://doi.org/10.14233/ajchem.2013.14917

Boris Pejin

Institute for Multidisciplinary Research, University of Belgrade, Belgrade, Serbia

Bojana Stanimirovic

MOL d.o.o., Belgrade, Serbia

Neda Djordjevic

Faculty of Chemistry, University of Belgrade, Belgrade, Serbia

Aleksandar Hegedis

Institute for Multidisciplinary Research, University of Belgrade, Belgrade, Serbia

Ivo Karaman

Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia

Mladen Horvatovic

Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia

Ksenija Radotic

Institute for Multidisciplinary Research, University of Belgrade, Belgrade, Serbia

Corresponding Author(s) : Boris Pejin

brspjn@gmail.com; borispejin@imsi.rs

Asian Journal of Chemistry, Vol. 25 No. 8 (2013): Vol 25 Issue 8
Article Published : March 19, 2013

Abstract

The objective of the present study was in vitro evaluation of radioprotective activity of the freshwater bryozoan Hyalinella punctata on cultured human peripheral blood lymphocytes after irradiation with 2 Gy of ⁶⁰Co g-rays. Since its water extract at concentration 0.001 mg/mL reduced the incidence of radiation-induced micronuclei for almost 30 %, it could be considered as a promising source of new natural products with the aforementioned activity. Both the content of sulphur (1.17 %), determined by gravimetric method and infrared absorption frequences (76 % similarity with those of bacitracin) of the investigated extract indicate the presence of organic sulphur compound(s) such as cyclic peptides and polypeptides which might be responsible for the observed radioprotection.

Keywords

Plumatellidae Extract Lymphocytes Ionising radiation

Pejin, B., Stanimirovic, B., Djordjevic, N., Hegedis, A., Karaman, I., Horvatovic, M., & Radotic, K. (2013). In vitro Radioprotective Activity of the Bryozoan Hyalinella punctata. Asian Journal of Chemistry, 25(8), 4713–4714. https://doi.org/10.14233/ajchem.2013.14917

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References

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J.S. Ryland, Bryozoans, Hutchinson University Library, London, pp. 175 (1970).
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V.M. Martinovic-Vitanovic, V.M. Milankov and V.I. Kalafatic, Limnologica, 40, 73 (2010).
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H.M. Patt, E.B. Tyree, R.L. Straube and D.E. Smith, Science, 110, 213 (1949).
B. Pejin, C. Iodice, G. Tommonaro and S. De Rosa, J. Nat. Prod., 71, 1850 (2008).
S. De Rosa, B. Pejin and G. Tommonaro, 4th International Conference on Oxidative Stress in Skin Medicine and Biology, Book of Abstracts, pp. 53 (2008).
B. Pejin, J. Glamoclija,A. Ciric, K Radotic, V. Vajs, V. Tesevic, A. Hegedis, I. Karaman, M. Horvatovic and M. Sokovic, Dig. J. Nanomater. Biostruct., 7, 1021 (2012).
Law on Health Care, Official Gazette of the Republic of Serbia, Parliament of the Republic of Serbia, pp. 107, 112 (2005).
M. Fenech, Mutat. Res., 285, 35 (1993).
J. Surrales, N. Xamena, A. Creus and R. Marco, Mutat. Res., 342, 43 (1995).
W. Rieman III and G. Hagen, Ind. Eng. Chem. Anal. Ed., 14, 150 (1942).
K. Dittman, M. Toulany, J. Classen, V. Heinrich, L. Milas and H.P. Rodermann, Strahlenther. Onkol., 181, 191 (2005).
J. Dunst, S. Semli, S. Pigorsch, A.C. Muller and T. Reese, Strahlenther. Onkol., 176, 416 (2000).
A. Vacek, V. Tacev and M. Hoffer, Strahlenther. Onkol., 177, 474 (2001).
S.M. Hahn, M.C. Krishna, A. Samuni, W. DeGraff, D.O. Cuscela, P. Johnstone and J.B. Mitchell, Cancer Res., 54, 2006S (1994).

References

C. Christophersen, in ed.: A. Brossi, Marine Alkaloids, The Alkaloids: Chemistry and Pharmacology, Academic Press, New York, pp. 25-112 (1985).

J.S. Ryland, Bryozoans, Hutchinson University Library, London, pp. 175 (1970).

X.-R. Tian, H.-F. Tang, Y.-S. Li, H.-W. Lin, X.-L. Chen, N. Ma, M.-N. Yao and P.-H. Zhang, Mar. Drugs, 9, 162 (2011).

T.S. Wood, in eds.: J. Thorp and A. Corvich, Bryozoans, Ecology and Classification of North American Freshwater Invertebrates, Academic Press, New York, pp. 505-525 (2001).

G. Markovic, T. Karan-•nidaršic and P. Simonovic, Polish J. Ecol., 57, 201 (2009).

V.M. Martinovic-Vitanovic, V.M. Milankov and V.I. Kalafatic, Limnologica, 40, 73 (2010).

S. Petrovic, A. Leskovac and G. Joksic, Curr. Sci. (India), 95, 1035 (2008).

H.M. Patt, E.B. Tyree, R.L. Straube and D.E. Smith, Science, 110, 213 (1949).

B. Pejin, C. Iodice, G. Tommonaro and S. De Rosa, J. Nat. Prod., 71, 1850 (2008).

S. De Rosa, B. Pejin and G. Tommonaro, 4th International Conference on Oxidative Stress in Skin Medicine and Biology, Book of Abstracts, pp. 53 (2008).

B. Pejin, J. Glamoclija,A. Ciric, K Radotic, V. Vajs, V. Tesevic, A. Hegedis, I. Karaman, M. Horvatovic and M. Sokovic, Dig. J. Nanomater. Biostruct., 7, 1021 (2012).

Law on Health Care, Official Gazette of the Republic of Serbia, Parliament of the Republic of Serbia, pp. 107, 112 (2005).

M. Fenech, Mutat. Res., 285, 35 (1993).

J. Surrales, N. Xamena, A. Creus and R. Marco, Mutat. Res., 342, 43 (1995).

W. Rieman III and G. Hagen, Ind. Eng. Chem. Anal. Ed., 14, 150 (1942).

K. Dittman, M. Toulany, J. Classen, V. Heinrich, L. Milas and H.P. Rodermann, Strahlenther. Onkol., 181, 191 (2005).

J. Dunst, S. Semli, S. Pigorsch, A.C. Muller and T. Reese, Strahlenther. Onkol., 176, 416 (2000).

A. Vacek, V. Tacev and M. Hoffer, Strahlenther. Onkol., 177, 474 (2001).

S.M. Hahn, M.C. Krishna, A. Samuni, W. DeGraff, D.O. Cuscela, P. Johnstone and J.B. Mitchell, Cancer Res., 54, 2006S (1994).

Issue

Vol. 25 No. 8 (2013): Vol 25 Issue 8

In vitro Radioprotective Activity of the Bryozoan Hyalinella punctata

Corresponding Author(s) : Boris Pejin

Abstract

Keywords

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